ABC transporter genes and risk of type 2 diabetes: a study of 40,000 individuals from the general population

Jesper Schou; Anne Tybjærg-Hansen; Holger Jon Møller; Børge G Nordestgaard; Ruth Frikke-Schmidt

doi:10.2337/dc12-0082

ABC transporter genes and risk of type 2 diabetes: a study of 40,000 individuals from the general population

Jesper Schou, Anne Tybjærg-Hansen, Holger Jon Møller, Børge G Nordestgaard, Ruth Frikke-Schmidt

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

30 Citationer (Scopus)

Abstract

Alterations of pancreatic β-cell cholesterol content may contribute to β-cell dysfunction. Two important determinants of intracellular cholesterol content are the ATP-binding cassette (ABC) transporters A1 (ABCA1) and -G1 (ABCG1). Whether genetic variation in ABCA1 and ABCG1 predicts risk of type 2 diabetes in the general population is unknown.

Originalsprog	Engelsk
Tidsskrift	Diabetes Care
Vol/bind	35
Udgave nummer	12
Sider (fra-til)	2600-6
Antal sider	7
ISSN	0149-5992
DOI	https://doi.org/10.2337/dc12-0082
Status	Udgivet - 2012

Adgang til dokumentet

10.2337/dc12-0082

Citationsformater

@article{a574dcd6c6d4444a8bc07f7cf4feddc2,

title = "ABC transporter genes and risk of type 2 diabetes: a study of 40,000 individuals from the general population",

abstract = "Alterations of pancreatic β-cell cholesterol content may contribute to β-cell dysfunction. Two important determinants of intracellular cholesterol content are the ATP-binding cassette (ABC) transporters A1 (ABCA1) and -G1 (ABCG1). Whether genetic variation in ABCA1 and ABCG1 predicts risk of type 2 diabetes in the general population is unknown.",

author = "Jesper Schou and Anne Tybj{\ae}rg-Hansen and M{\o}ller, {Holger Jon} and Nordestgaard, {B{\o}rge G} and Ruth Frikke-Schmidt",

year = "2012",

doi = "10.2337/dc12-0082",

language = "English",

volume = "35",

pages = "2600--6",

journal = "Diabetes Care",

issn = "0149-5992",

publisher = "American Diabetes Association",

number = "12",

}

TY - JOUR

T1 - ABC transporter genes and risk of type 2 diabetes

T2 - a study of 40,000 individuals from the general population

AU - Schou, Jesper

AU - Tybjærg-Hansen, Anne

AU - Møller, Holger Jon

AU - Nordestgaard, Børge G

AU - Frikke-Schmidt, Ruth

PY - 2012

Y1 - 2012

N2 - Alterations of pancreatic β-cell cholesterol content may contribute to β-cell dysfunction. Two important determinants of intracellular cholesterol content are the ATP-binding cassette (ABC) transporters A1 (ABCA1) and -G1 (ABCG1). Whether genetic variation in ABCA1 and ABCG1 predicts risk of type 2 diabetes in the general population is unknown.

AB - Alterations of pancreatic β-cell cholesterol content may contribute to β-cell dysfunction. Two important determinants of intracellular cholesterol content are the ATP-binding cassette (ABC) transporters A1 (ABCA1) and -G1 (ABCG1). Whether genetic variation in ABCA1 and ABCG1 predicts risk of type 2 diabetes in the general population is unknown.

U2 - 10.2337/dc12-0082

DO - 10.2337/dc12-0082

M3 - Journal article

C2 - 23139370

VL - 35

SP - 2600

EP - 2606

JO - Diabetes Care

JF - Diabetes Care

SN - 0149-5992

IS - 12

ER -