Aberrant expression of mucin core proteins and o-linked glycans associated with progression of pancreatic cancer

Neeley Remmers; Judy M Anderson; Erin M Linde; Dominick J DiMaio; Audrey J Lazenby; Hans H Wandall; Ulla Mandel; Henrik Clausen; Fang Yu; Michael A Hollingsworth

doi:10.1158/1078-0432.CCR-12-2662

Aberrant expression of mucin core proteins and o-linked glycans associated with progression of pancreatic cancer

Neeley Remmers, Judy M Anderson, Erin M Linde, Dominick J DiMaio, Audrey J Lazenby, Hans H Wandall, Ulla Mandel, Henrik Clausen, Fang Yu, Michael A Hollingsworth

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

138 Citationer (Scopus)

Abstract

Mucin expression is a common feature of most adenocarcinomas and features prominently in current attempts to improve diagnosis and therapy for pancreatic cancer and other adenocarcinomas. We investigated the expression of a number of mucin core proteins and associated O-linked glycans expressed in pancreatic adenocarcinoma-sialyl Tn (STn), Tn, T antigen, sialyl Lewis A (CA19-9), sialyl Lewis C (SLeC), Lewis X (LeX), and sialyl LeX (SLeX)-during the progression of pancreatic cancer from early stages to metastatic disease.

Originalsprog	Engelsk
Tidsskrift	Clinical Cancer Research
Vol/bind	19
Udgave nummer	8
Sider (fra-til)	1981-93
Antal sider	13
ISSN	1078-0432
DOI	https://doi.org/10.1158/1078-0432.CCR-12-2662
Status	Udgivet - 15 apr. 2013

Adgang til dokumentet

10.1158/1078-0432.CCR-12-2662

Citationsformater

Aberrant expression of mucin core proteins and o-linked glycans associated with progression of pancreatic cancer. / Remmers, Neeley; Anderson, Judy M; Linde, Erin M; DiMaio, Dominick J; Lazenby, Audrey J; Wandall, Hans H ; Mandel, Ulla ; Clausen, Henrik; Yu, Fang; Hollingsworth, Michael A.

I: Clinical Cancer Research, Bind 19, Nr. 8, 15.04.2013, s. 1981-93.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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abstract = "Mucin expression is a common feature of most adenocarcinomas and features prominently in current attempts to improve diagnosis and therapy for pancreatic cancer and other adenocarcinomas. We investigated the expression of a number of mucin core proteins and associated O-linked glycans expressed in pancreatic adenocarcinoma-sialyl Tn (STn), Tn, T antigen, sialyl Lewis A (CA19-9), sialyl Lewis C (SLeC), Lewis X (LeX), and sialyl LeX (SLeX)-during the progression of pancreatic cancer from early stages to metastatic disease.",

author = "Neeley Remmers and Anderson, {Judy M} and Linde, {Erin M} and DiMaio, {Dominick J} and Lazenby, {Audrey J} and Wandall, {Hans H} and Ulla Mandel and Henrik Clausen and Fang Yu and Hollingsworth, {Michael A}",

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T1 - Aberrant expression of mucin core proteins and o-linked glycans associated with progression of pancreatic cancer

AU - Remmers, Neeley

AU - Anderson, Judy M

AU - Linde, Erin M

AU - DiMaio, Dominick J

AU - Lazenby, Audrey J

AU - Wandall, Hans H

AU - Mandel, Ulla

AU - Clausen, Henrik

AU - Yu, Fang

AU - Hollingsworth, Michael A

PY - 2013/4/15

Y1 - 2013/4/15

N2 - Mucin expression is a common feature of most adenocarcinomas and features prominently in current attempts to improve diagnosis and therapy for pancreatic cancer and other adenocarcinomas. We investigated the expression of a number of mucin core proteins and associated O-linked glycans expressed in pancreatic adenocarcinoma-sialyl Tn (STn), Tn, T antigen, sialyl Lewis A (CA19-9), sialyl Lewis C (SLeC), Lewis X (LeX), and sialyl LeX (SLeX)-during the progression of pancreatic cancer from early stages to metastatic disease.

AB - Mucin expression is a common feature of most adenocarcinomas and features prominently in current attempts to improve diagnosis and therapy for pancreatic cancer and other adenocarcinomas. We investigated the expression of a number of mucin core proteins and associated O-linked glycans expressed in pancreatic adenocarcinoma-sialyl Tn (STn), Tn, T antigen, sialyl Lewis A (CA19-9), sialyl Lewis C (SLeC), Lewis X (LeX), and sialyl LeX (SLeX)-during the progression of pancreatic cancer from early stages to metastatic disease.

U2 - 10.1158/1078-0432.CCR-12-2662

DO - 10.1158/1078-0432.CCR-12-2662

M3 - Journal article

C2 - 23446997

VL - 19

SP - 1981

EP - 1993

JO - Clinical Cancer Research

JF - Clinical Cancer Research

SN - 1078-0432

IS - 8

ER -