Absence of NR2E1 mutations in patients with aniridia

Ximena Corso-Díaz, Adrienne E Borrie, Russell Bonaguro, Johanna M Schuetz, Thomas Rosenberg, Hanne Jensen, Brian P Brooks, Ian M Macdonald, Francesca Pasutto, Michael A Walter, Karen Grønskov, Angela Brooks-Wilson, Elizabeth M Simpson

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Abstract

Nuclear receptor 2E1 (NR2E1) is a transcription factor with many roles during eye development and thus may be responsible for the occurrence of certain congenital eye disorders in humans. To test this hypothesis, we screened NR2E1 for candidate mutations in patients with aniridia and other congenital ocular malformations (anterior segment dysgenesis, congenital optic nerve malformation, and microphthalmia).
OriginalsprogEngelsk
TidsskriftMolecular Vision
Vol/bind18
Sider (fra-til)2770-82
Antal sider13
ISSN1090-0535
StatusUdgivet - 2012

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