TY - JOUR
T1 - Acquisition of natural humoral immunity to P. falciparum in early life in Benin
T2 - impact of clinical, environmental and host factors
AU - Dechavanne, Célia
AU - Sadissou, Ibrahim
AU - Bouraima, Aziz
AU - Ahouangninou, Claude
AU - Amoussa, Roukiyath
AU - Milet, Jacqueline
AU - Moutairou, Kabirou
AU - Massougbodji, Achille
AU - Theisen, Michael
AU - Remarque, Edmond J
AU - Courtin, David
AU - Nuel, Gregory
AU - Migot-Nabias, Florence
AU - Garcia, André
PY - 2016
Y1 - 2016
N2 - To our knowledge, effects of age, placental malaria infection, infections during follow-up, nutritional habits, sickle-cell trait and individual exposure to Anopheles bites were never explored together in a study focusing on the acquisition of malaria antibody responses among infants living in endemic areas.Five hundred and sixty-seven Beninese infants were weekly followed-up from birth to 18 months of age. Immunoglobulin G (IgG), IgG1 and IgG3 specific for 5 malaria antigens were measured every 3 months. A linear mixed model was used to analyze the effect of each variable on the acquisition of antimalarial antibodies in 6-to18-month old infants in univariate and multivariate analyses. Placental malaria, nutrition intakes and sickle-cell trait did not influence the infant antibody levels to P. falciparum antigens. In contrary, age, malaria antibody levels at birth, previous and present malaria infections as well as exposure to Anopheles bites were significantly associated with the natural acquisition of malaria antibodies in 6-to18-month old Beninese infants. This study highlighted inescapable factors to consider simultaneously in an immuno-epidemiological study or a vaccine trial in early life.
AB - To our knowledge, effects of age, placental malaria infection, infections during follow-up, nutritional habits, sickle-cell trait and individual exposure to Anopheles bites were never explored together in a study focusing on the acquisition of malaria antibody responses among infants living in endemic areas.Five hundred and sixty-seven Beninese infants were weekly followed-up from birth to 18 months of age. Immunoglobulin G (IgG), IgG1 and IgG3 specific for 5 malaria antigens were measured every 3 months. A linear mixed model was used to analyze the effect of each variable on the acquisition of antimalarial antibodies in 6-to18-month old infants in univariate and multivariate analyses. Placental malaria, nutrition intakes and sickle-cell trait did not influence the infant antibody levels to P. falciparum antigens. In contrary, age, malaria antibody levels at birth, previous and present malaria infections as well as exposure to Anopheles bites were significantly associated with the natural acquisition of malaria antibodies in 6-to18-month old Beninese infants. This study highlighted inescapable factors to consider simultaneously in an immuno-epidemiological study or a vaccine trial in early life.
U2 - 10.1038/srep33961
DO - 10.1038/srep33961
M3 - Journal article
C2 - 27670685
VL - 6
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
M1 - 33961
ER -