TY - JOUR
T1 - Activated T lymphocytes disappear from circulation during endotoxemia in humans
AU - Suarez Krabbe, Karen
AU - Kemp, Helle Bruunsgaard
AU - Qvist, Jesper
AU - Fonsmark, Lise
AU - Møller, Kirsten
AU - Hansen, Christian Muff
AU - Skinhøj, Peter
AU - Pedersen, Bente Klarlund
PY - 2002/12/31
Y1 - 2002/12/31
N2 - Seventeen volunteers received an intravenous bolus of endotoxin (2 ng/kg of body weight). Endotoxin-induced lymphopenia was constituted mainly by cells with an immature phenotype (CD45RA(+) CD45RO(-)) that were less likely to undergo apoptosis (CD28(+)), whereas cells with the highest rates of disappearance were characterized by an activated phenotype (CD45RA(-) CD45RO(+)) as well as a phenotype linked to apoptosis (CD95(+) CD28(-)). In conclusion, endotoxin-induced lymphopenia reflects the disappearance from the circulation of activated lymphocytes prone to undergo apoptosis.
AB - Seventeen volunteers received an intravenous bolus of endotoxin (2 ng/kg of body weight). Endotoxin-induced lymphopenia was constituted mainly by cells with an immature phenotype (CD45RA(+) CD45RO(-)) that were less likely to undergo apoptosis (CD28(+)), whereas cells with the highest rates of disappearance were characterized by an activated phenotype (CD45RA(-) CD45RO(+)) as well as a phenotype linked to apoptosis (CD95(+) CD28(-)). In conclusion, endotoxin-induced lymphopenia reflects the disappearance from the circulation of activated lymphocytes prone to undergo apoptosis.
M3 - Tidsskriftartikel
SN - 1556-6811
VL - 9
SP - 731
EP - 735
JO - Clinical and Vaccine Immunology
JF - Clinical and Vaccine Immunology
IS - 3
ER -