@article{e54bd780abeb11ddb5e9000ea68e967b,
title = "Active lithium transport by rat renal proximal tubule: a micropuncture study.",
abstract = "We tested the hypothesis that proximal tubular Li+ reabsorption is due to passive transport. Clearances of [14C]inulin (CIn) and Li+ (CLi), proximal transepithelial electrical potential difference (PD), and tubular fluid-to-plasma Li+ concentration ratios [(TF/P)Li] were measured in anesthetized rats before and after induction of osmotic mannitol diuresis. Late proximal (TF/P)Li was measured after acute intravenous LiCl administration and after addition of LiCl to the diet for 2 days. Glomerular filtration rate (CIn) decreased, whereas CNa and CLi increased during osmotic diuresis. Control early proximal PD was -0.6 mV (lumen negative); late proximal PD (PDLP) was 1.1 mV (lumen positive). PDLP decreased by 1.5 mV to -0.4 mV (lumen negative) after mannitol infusion. Late proximal (TF/P)Li was 1.01 after oral Li+, 1.16 after intravenous Li+ (P < 0.01), and 1.00 during osmotic diuresis. It is concluded that proximal Li+ transfer is distinct from that of Na+, closely parallels proximal water transfer, and involves an active transport mechanism independent of the PD. The data suggest that acute elevation of plasma Li+ concentration may activate a delayed Li+ transport pathway in the proximal convoluted tubule.",
author = "Leyssac, {P P} and O Frederiksen and Holstein-Rathlou, {N H} and Alfrey, {A C} and P Christensen",
note = "Keywords: Anesthesia; Animals; Biological Transport, Active; Diet; Diuresis; Electrochemistry; Halothane; Injections, Intravenous; Kidney Tubules, Proximal; Lithium; Male; Mannitol; Punctures; Rats; Rats, Inbred Strains; Thiopental",
year = "1994",
language = "English",
volume = "267",
pages = "F86--93",
journal = "American Journal of Physiology - Cell Physiology",
issn = "0363-6143",
publisher = "American Physiological Society",
number = "1 Pt 2",
}