Acute changes in plasma glucose increases left ventricular systolic function in insulin-treated patients with type 2 diabetes and controls

Andreas Andersen; Peter G. Jørgensen; Jonatan Bagger; Maria P. A. Baldassarre; Mikkel B. Christensen; Ulrik Pedersen-Bjergaard; Tommi B. Lindhardt; Gunnar Gislason; Filip K. Knop; Tina Vilsbøll

doi:10.1111/dom.14682

Acute changes in plasma glucose increases left ventricular systolic function in insulin-treated patients with type 2 diabetes and controls

Andreas Andersen, Peter G. Jørgensen, Jonatan Bagger, Maria P. A. Baldassarre, Mikkel B. Christensen, Ulrik Pedersen-Bjergaard, Tommi B. Lindhardt, Gunnar Gislason, Filip K. Knop, Tina Vilsbøll^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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Abstract

Aims We aimed to evaluate the effect of acute hyperglycaemia and hypoglycaemia on cardiac function in patients with type 2 diabetes (T2D) and a control group. Materials and methods In a nonrandomized interventional study, insulin-treated patients with T2D (N = 21, mean +/- SD age 62.8 +/- 6.5 years, body mass index [BMI] 29.0 +/- 4.2 kg/m(2), glycated haemoglobin [HbA1c] 51.0 +/- 5.4 mmol/mol [6.8 +/- 0.5%]) and matched controls (N = 21, mean +/- SD age 62.2 +/- 8.3 years, BMI 29.2 +/- 3.5 kg/m(2), HbA1c 34.3 +/- 3.3 mmol/L [5.3 +/- 0.3%]) underwent one experimental day with plasma glucose (PG) clamped at three different 30-minute steady-state levels: (1) fasting plasma glucose (FPG); (2) hyperglycaemia (FPG + 10 mmol/L); and (3) hyperinsulinaemic hypoglycaemia (PG

Originalsprog	Engelsk
Tidsskrift	Diabetes, Obesity and Metabolism
Vol/bind	24
Udgave nummer	6
Sider (fra-til)	1123-1131
ISSN	1462-8902
DOI	https://doi.org/10.1111/dom.14682
Status	Udgivet - 2022

Adgang til dokumentet

10.1111/dom.14682Licens: CC BY-NC

FulltextForlagets udgivne version, 849 KBLicens: CC BY-NC

Citationsformater

Andersen, A., Jørgensen, P. G., Bagger, J., Baldassarre, M. P. A., Christensen, M. B., Pedersen-Bjergaard, U., Lindhardt, T. B., Gislason, G., Knop, F. K., & Vilsbøll, T. (2022). Acute changes in plasma glucose increases left ventricular systolic function in insulin-treated patients with type 2 diabetes and controls. Diabetes, Obesity and Metabolism, 24(6), 1123-1131. https://doi.org/10.1111/dom.14682

Acute changes in plasma glucose increases left ventricular systolic function in insulin-treated patients with type 2 diabetes and controls. / Andersen, Andreas; Jørgensen, Peter G.; Bagger, Jonatan; Baldassarre, Maria P. A.; Christensen, Mikkel B.; Pedersen-Bjergaard, Ulrik; Lindhardt, Tommi B.; Gislason, Gunnar ; Knop, Filip K.; Vilsbøll, Tina.

I: Diabetes, Obesity and Metabolism, Bind 24, Nr. 6, 2022, s. 1123-1131.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Andersen, A, Jørgensen, PG, Bagger, J, Baldassarre, MPA, Christensen, MB , Pedersen-Bjergaard, U, Lindhardt, TB, Gislason, G , Knop, FK & Vilsbøll, T 2022, 'Acute changes in plasma glucose increases left ventricular systolic function in insulin-treated patients with type 2 diabetes and controls', Diabetes, Obesity and Metabolism, bind 24, nr. 6, s. 1123-1131. https://doi.org/10.1111/dom.14682

Andersen, Andreas ; Jørgensen, Peter G. ; Bagger, Jonatan ; Baldassarre, Maria P. A. ; Christensen, Mikkel B. ; Pedersen-Bjergaard, Ulrik ; Lindhardt, Tommi B. ; Gislason, Gunnar ; Knop, Filip K. ; Vilsbøll, Tina. / Acute changes in plasma glucose increases left ventricular systolic function in insulin-treated patients with type 2 diabetes and controls. I: Diabetes, Obesity and Metabolism. 2022 ; Bind 24, Nr. 6. s. 1123-1131.

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abstract = "Aims We aimed to evaluate the effect of acute hyperglycaemia and hypoglycaemia on cardiac function in patients with type 2 diabetes (T2D) and a control group. Materials and methods In a nonrandomized interventional study, insulin-treated patients with T2D (N = 21, mean +/- SD age 62.8 +/- 6.5 years, body mass index [BMI] 29.0 +/- 4.2 kg/m(2), glycated haemoglobin [HbA1c] 51.0 +/- 5.4 mmol/mol [6.8 +/- 0.5%]) and matched controls (N = 21, mean +/- SD age 62.2 +/- 8.3 years, BMI 29.2 +/- 3.5 kg/m(2), HbA1c 34.3 +/- 3.3 mmol/L [5.3 +/- 0.3%]) underwent one experimental day with plasma glucose (PG) clamped at three different 30-minute steady-state levels: (1) fasting plasma glucose (FPG); (2) hyperglycaemia (FPG + 10 mmol/L); and (3) hyperinsulinaemic hypoglycaemia (PG",

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T1 - Acute changes in plasma glucose increases left ventricular systolic function in insulin-treated patients with type 2 diabetes and controls

AU - Andersen, Andreas

AU - Jørgensen, Peter G.

AU - Bagger, Jonatan

AU - Baldassarre, Maria P. A.

AU - Christensen, Mikkel B.

AU - Pedersen-Bjergaard, Ulrik

AU - Lindhardt, Tommi B.

AU - Gislason, Gunnar

AU - Knop, Filip K.

AU - Vilsbøll, Tina

PY - 2022

Y1 - 2022

N2 - Aims We aimed to evaluate the effect of acute hyperglycaemia and hypoglycaemia on cardiac function in patients with type 2 diabetes (T2D) and a control group. Materials and methods In a nonrandomized interventional study, insulin-treated patients with T2D (N = 21, mean +/- SD age 62.8 +/- 6.5 years, body mass index [BMI] 29.0 +/- 4.2 kg/m(2), glycated haemoglobin [HbA1c] 51.0 +/- 5.4 mmol/mol [6.8 +/- 0.5%]) and matched controls (N = 21, mean +/- SD age 62.2 +/- 8.3 years, BMI 29.2 +/- 3.5 kg/m(2), HbA1c 34.3 +/- 3.3 mmol/L [5.3 +/- 0.3%]) underwent one experimental day with plasma glucose (PG) clamped at three different 30-minute steady-state levels: (1) fasting plasma glucose (FPG); (2) hyperglycaemia (FPG + 10 mmol/L); and (3) hyperinsulinaemic hypoglycaemia (PG

AB - Aims We aimed to evaluate the effect of acute hyperglycaemia and hypoglycaemia on cardiac function in patients with type 2 diabetes (T2D) and a control group. Materials and methods In a nonrandomized interventional study, insulin-treated patients with T2D (N = 21, mean +/- SD age 62.8 +/- 6.5 years, body mass index [BMI] 29.0 +/- 4.2 kg/m(2), glycated haemoglobin [HbA1c] 51.0 +/- 5.4 mmol/mol [6.8 +/- 0.5%]) and matched controls (N = 21, mean +/- SD age 62.2 +/- 8.3 years, BMI 29.2 +/- 3.5 kg/m(2), HbA1c 34.3 +/- 3.3 mmol/L [5.3 +/- 0.3%]) underwent one experimental day with plasma glucose (PG) clamped at three different 30-minute steady-state levels: (1) fasting plasma glucose (FPG); (2) hyperglycaemia (FPG + 10 mmol/L); and (3) hyperinsulinaemic hypoglycaemia (PG

KW - ACUTE HYPERGLYCEMIA

KW - INDUCED HYPOGLYCEMIA

KW - RESPONSES

KW - RISK

U2 - 10.1111/dom.14682

DO - 10.1111/dom.14682

M3 - Journal article

C2 - 35238140

VL - 24

SP - 1123

EP - 1131

JO - Diabetes, Obesity and Metabolism

JF - Diabetes, Obesity and Metabolism

SN - 1462-8902

IS - 6

ER -