@article{1529ebc0a19911dd95e9000ea68e967b,
title = "Acute P. falciparum malaria induces a loss of CD28- T IFN-¿ producing cells",
abstract = "P. falciparum malaria is associated with increased activation among peripheral lymphocytes. In the present study, we investigated markers of susceptibility to apoptosis and expression of IFN-gamma and IL-4 by CD28-and CD28+T cells in West African children with acute P. falciparum malaria. The study showed increased susceptibility to apoptosis and cytokine production among T lymphocytes during acute malaria but also that T cells, in particular IFN-gamma producing CD28-T cells, were substantially reduced. These results are in line with previous studies suggesting that certain T cell subsets are sequestered away from the peripheral blood during P. falciparum malaria.",
author = "K{\aa}re Kemp and Akanmori, {Bartholomew D} and Kurtzhals, {J{\o}rgen A L} and Victoria Adabayeri and Goka, {Bamenla Q} and Lars Hviid",
note = "Keywords: Acute Disease; Animals; Antigens, CD28; Antigens, CD95; Apoptosis; Genes, bcl-2; Humans; Interferon Type II; Interleukin-4; Malaria, Falciparum; Plasmodium falciparum; T-Lymphocyte Subsets; T-Lymphocytes",
year = "2002",
language = "English",
volume = "24",
pages = "545--8",
journal = "Parasite Immunology",
issn = "0141-9838",
publisher = "Wiley-Blackwell",
number = "11-12",
}