Abstract
Background: Several studies have investigated a possible association between respiratory infection and acute myocardial infarction (MI). As both influenza and pneumococcal infections are vaccine preventable, understanding the populations affected by virus-induced cardiovascular complications is important to guide public health and clinical practice. Aim: This observational study aimed to quantify the association between laboratory-confirmed respiratory bacteria or virus infections and risk of first MI or stroke, by using self-controlled case series (SCCS) analysis of anonymised linked electronic Danish health records. Methods: The SCCS method was used to determine the relative incidence of the first event of MI and stroke occurring within 28days after laboratory-confirmed respiratory infections compared with the baseline time period. Results: In the age and season adjusted analyses for first acute MI, the incidence ratios (IR) of a MI event occurring during the risk period were significantly elevated following a Streptococcus pneumoniae infection with values of 20.1, 11.0 and 4.9 during 1-3, 4-7 and 8-14days, respectively and following respiratory virus infection with values of 15.2, 4.5 and 4.4 during 1-3, 8-14 and 15-28days, respectively. The significantly elevated IRs for stroke following an S. pneumoniae infection were 25.5 and 6.3 during 1-3 and 8-14days, respectively and following respiratory virus infection 8.3, 7.8 and 6.2 during 1-3, 4-7 and 8-14days, respectively. Conclusion: This study suggested a significant cardiovascular event triggering effect following infection with S. pneumoniae and respiratory viruses (mainly influenza), indicating the importance of protection against vaccine-preventable respiratory infections.
Originalsprog | Engelsk |
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Artikelnummer | 1900199 |
Tidsskrift | Eurosurveillance |
Vol/bind | 25 |
Udgave nummer | 17 |
ISSN | 1025-496X |
DOI | |
Status | Udgivet - 2020 |
Bibliografisk note
Funding Information:Funding statement: This work was funded by an Academy of Medical Sciences Starter Grant to Clinical Lecturers to CWG. CWG is supported by a Wellcome Intermediate Clinical Fellowship (201440_Z_16_Z). RMB is supported by a UKRI Innovation Fellowship funded by the Medical Research Council, UK (MR/S003797/1)
Publisher Copyright:
© 2020 European Centre for Disease Prevention and Control (ECDC). All rights reserved.