Advanced therapies in orthopaedics

Tobias Winkler*, Sven Geissler, Tazio Maleitzke, Carsten Perka, Georg N. Duda, Alexander Hildebrandt

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

1 Citationer (Scopus)
3 Downloads (Pure)

Abstract

Advanced therapies are expected to play a crucial role in supporting repair after injury, halting the degeneration of musculoskeletal tissue to enable and promote physical activity.

Despite advancements, the progress in developing advanced therapies in orthopaedics lags behind specialties like oncology, since innovative regenerative treatment strategies fall short of their expectations in musculoskeletal clinical trials.

Researchers should focus on understanding the mechanism of action behind the investigated target before conducting clinical trials.

Strategic research networks are needed that not only enhance scientific exchange among like-minded researchers but need to include early on commercial views, companies and venture perspectives, regulatory insights and reimbursement perspectives. Only in such collaborations essential roadblocks towards clinical trials and go-to-patients be overcome.

Keywords: advanced therapies; biomaterials; cell therapy; degeneration; gene therapy; orthobiologics
OriginalsprogEngelsk
TidsskriftEFORT Open Reviews
Vol/bind9
Udgave nummer9
Sider (fra-til)837-844
Antal sider8
ISSN2396-7544
DOI
StatusUdgivet - 2024

Bibliografisk note

Funding Information:
This study was partly funded by the DFG Collaborative Research Center 1444, German Federal Ministry of Education and Research (grant no. 031L0234B) and the European Union under grant agreement no. 101095635 (PROTO). Views and opinions expressed are however those of the authors only and do not necessarily reflect those of the European Union or the European Health and Digital Executive Agency (HADEA). Neither the European Union nor the granting authority can be held responsible for them. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Publisher Copyright:
© 2024 the author(s)

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