Abstract
Objectives: Elderly patients with hematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection's impact on different age groups remains unstudied in detail. Methods: We analyzed elderly patients (age groups: 65-70, 71-75, 76-80, and >80 years old) with hematologic malignancies included in the EPICOVIDEHA registry between January 2020 and July 2022. Univariable and multivariable Cox regression models were conducted to identify factors influencing death in COVID-19 patients with hematological malignancy. Results: The study included data from 3,603 elderly patients (aged 65 or older) with hematological malignancy, with a majority being male (58.1%) and a significant proportion having comorbidities. The patients were divided into four age groups, and the analysis assessed COVID-19 outcomes, vaccination status, and other variables in relation to age and pandemic waves. The 90-day survival rate for patients with COVID-19 was 71.2%, with significant differences between groups. The pandemic waves had varying impacts, with the first wave affecting patients over 80 years old, the second being more severe in 65-70, and the third being the least severe in all age groups. Factors contributing to 90-day mortality included age, comorbidities, lymphopenia, active malignancy, acute leukemia, less than three vaccine doses, severe COVID-19, and using only corticosteroids as treatment. Conclusion: These data underscore the heterogeneity of elderly hematological patients, highlight the different impacts of COVID-19 waves and the pivotal importance of vaccination, and may help in planning future healthcare efforts.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | International Journal of Infectious Diseases |
| Vol/bind | 137 |
| Sider (fra-til) | 98-110 |
| Antal sider | 13 |
| ISSN | 1201-9712 |
| DOI | |
| Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:EPICOVIDEHA has received funds from Optics COMMIT (COVID-19 Unmet Medical Needs and Associated Research Extension) COVID-19 RFP program by GILEAD Science, United States (Project 2020-8223).
Publisher Copyright:
© 2023 The Author(s)
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Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients : EPICOVIDEHA findings. / Rossi, Giuseppe; Salmanton-García, Jon; Cattaneo, Chiara; Marchesi, Francesco; Dávila-Valls, Julio; Martín-Pérez, Sonia; Itri, Federico; López-García, Alberto; Glenthøj, Andreas; da Silva, Maria Gomes; Besson, Caroline; Marchetti, Monia; Weinbergerová, Barbora; Jaksic, Ozren; Jiménez, Moraima; Bilgin, Yavuz M.; Van Doesum, Jaap; Farina, Francesca; Žák, Pavel; Verga, Luisa; Collins, Graham P.; Bonuomo, Valentina; Van Praet, Jens; Nucci, Marcio; Meers, Stef; Espigado, Ildefonso; Fracchiolla, Nicola S.; Valković, Toni; Poulsen, Christian Bjørn; Čolović, Natasha; Dragonetti, Giulia; Ledoux, Marie Pierre; Tascini, Carlo; Buquicchio, Caterina; Blennow, Ola; Passamonti, Francesco; Machado, Marina; Labrador, Jorge; Duarte, Rafael F.; Schönlein, Martin; Prezioso, Lucia; Falces-Romero, Iker; Kulasekararaj, Austin; Garcia-Vidal, Carolina; Fernández, Noemí; Abu-Zeinah, Ghaith; Ormazabal-Vélez, Irati; Adžić-Vukičević, Tatjana; Piukovics, Klára; Stoma, Igor; Cuccaro, Annarosa; Magliano, Gabriele; Szotkowski, Tomáš; González-López, Tomás José; El-Ashwah, Shaimaa; Bergantim, Rui; Sili, Uluhan; Maertens, Johan; Demirkan, Fatih; De Ramón, Cristina; Petzer, Verena; Del Principe, Maria Ilaria; Navrátil, Milan; Dargenio, Michelina; Seval, Guldane Cengiz; Samarkos, Michail; Ráčil, Zdeněk; Pinczés, László Imre; Lahmer, Tobias; Busca, Alessandro; Méndez, Gustavo Adolfo; Vena, Antonio; Biernat, Monika M.; Merelli, Maria; Calbacho, Maria; Barać, Aleksandra; Bavastro, Martina; Limongelli, Alessandro; Ilhan, Osman; Wolf, Dominik; Çolak, Gökçe Melis; García-Sanz, Ramón; Emarah, Ziad; Mišković, Bojana; Gräfe, Stefanie K.; Mladenović, Miloš; Aiello, Tommaso Francesco; Núñez-Martín-Buitrago, Lucía; Nordlander, Anna; Arellano, Elena; Zambrotta, Giovanni Paolo Maria; Ammatuna, Emanuele; Cabirta, Alba; Sacchi, Maria Vittoria; Rodrigues, Raquel Nunes; Hersby, Ditte Stampe; Hanakova, Michaela; Rahimli, Laman; Cordoba, Raul; Cornely, Oliver A.; Pagano, Livio; Marques De Almeida, Joyce; Hernández-Rivas, José Ángel; Guidetti, Anna; Finizio, Olimpia; Stojanoski, Zlate; Cvetanoski, Milche; Meletiadis, Joseph; de Jonge, Nick; Antić, Darko; Ali, Natasha; Tisi, Maria Chiara; Serrano, Laura; Plantefeve, Gaëtan; Khanna, Nina; Hoenigl, Martin; Čerňan, Martin; Miranda-Castillo, Carolina; Fernández-Galán, María; Ser-Ris, Alexandra; Erben, Nurettin; Duléry, Rémy; Aujayeb, Avinash; Papa, Mario Virgilio; Novák, Jan; Delia, Mario; Sapienza, Giuseppe; Reizine, Florian; Omrani, Ali S.; Di Blasi, Roberta; Lamure, Sylvain; Drgoňa, Ľuboš; Coppola, Nicola; Batinić, Josip; Al-Khabori, Murtadha; Ribera-Santa Susana, José María; Piedimonte, Monica; Loureiro-Amigo, Jorge; Fouquet, Guillemette; Fazzi, Rita; Danion, François; Schubert, Jörg; Hoell-Neugebauer, Baerbel; Bahr, Nathan C.; Yahia, Ayel Omar; Torres-Atienza, Ana; Rinaldi, Ikhwan; Popova, Marina; Ommen, Hans Beier; Mitra, Maria Enza; Mikulska, Malgorzata; Lacej, Ira; Khostelidi, Sofya; Win, Sein; Vinh, Donald; Saleh, Modar; Prattes, Juergen; Jindra, Pavel; Guolo, Fabio; della Pepa, Roberta; Chelysheva, Ekaterina; Zdziarski, Przemyslaw; Wai-Man, Vivien; Soto-Silva, Andrés; Orth, Hans Martin; Malak, Sandra; Lorenzo De La Peña, Lisset; Kolditz, Martin; Kho, Chi Shan; Heath, Christopher H.; Groh, Ana; Gavriilaki, Eleni; Fung, Monica; Egger, Matthias; de Kort, Elizabeth; de Cabo, Erik; Cushion, Tania; Chowdhury, Fazle Rabbi; Ceesay, M. Mansour; Brehon, Mathias; Varricchio, Gina; Tafuri, Agostino; Jiménez-Lorenzo, María Josefa; Klimko, Nikolai; Tsirigotis, Panagiotis; Antoniadou, Anastasia; Vehreschild, Maria.
I: International Journal of Infectious Diseases, Bind 137, 2023, s. 98-110.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
}
TY - JOUR
T1 - Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients
T2 - EPICOVIDEHA findings
AU - Rossi, Giuseppe
AU - Salmanton-García, Jon
AU - Cattaneo, Chiara
AU - Marchesi, Francesco
AU - Dávila-Valls, Julio
AU - Martín-Pérez, Sonia
AU - Itri, Federico
AU - López-García, Alberto
AU - Glenthøj, Andreas
AU - da Silva, Maria Gomes
AU - Besson, Caroline
AU - Marchetti, Monia
AU - Weinbergerová, Barbora
AU - Jaksic, Ozren
AU - Jiménez, Moraima
AU - Bilgin, Yavuz M.
AU - Van Doesum, Jaap
AU - Farina, Francesca
AU - Žák, Pavel
AU - Verga, Luisa
AU - Collins, Graham P.
AU - Bonuomo, Valentina
AU - Van Praet, Jens
AU - Nucci, Marcio
AU - Meers, Stef
AU - Espigado, Ildefonso
AU - Fracchiolla, Nicola S.
AU - Valković, Toni
AU - Poulsen, Christian Bjørn
AU - Čolović, Natasha
AU - Dragonetti, Giulia
AU - Ledoux, Marie Pierre
AU - Tascini, Carlo
AU - Buquicchio, Caterina
AU - Blennow, Ola
AU - Passamonti, Francesco
AU - Machado, Marina
AU - Labrador, Jorge
AU - Duarte, Rafael F.
AU - Schönlein, Martin
AU - Prezioso, Lucia
AU - Falces-Romero, Iker
AU - Kulasekararaj, Austin
AU - Garcia-Vidal, Carolina
AU - Fernández, Noemí
AU - Abu-Zeinah, Ghaith
AU - Ormazabal-Vélez, Irati
AU - Adžić-Vukičević, Tatjana
AU - Piukovics, Klára
AU - Stoma, Igor
AU - Cuccaro, Annarosa
AU - Magliano, Gabriele
AU - Szotkowski, Tomáš
AU - González-López, Tomás José
AU - El-Ashwah, Shaimaa
AU - Bergantim, Rui
AU - Sili, Uluhan
AU - Maertens, Johan
AU - Demirkan, Fatih
AU - De Ramón, Cristina
AU - Petzer, Verena
AU - Del Principe, Maria Ilaria
AU - Navrátil, Milan
AU - Dargenio, Michelina
AU - Seval, Guldane Cengiz
AU - Samarkos, Michail
AU - Ráčil, Zdeněk
AU - Pinczés, László Imre
AU - Lahmer, Tobias
AU - Busca, Alessandro
AU - Méndez, Gustavo Adolfo
AU - Vena, Antonio
AU - Biernat, Monika M.
AU - Merelli, Maria
AU - Calbacho, Maria
AU - Barać, Aleksandra
AU - Bavastro, Martina
AU - Limongelli, Alessandro
AU - Ilhan, Osman
AU - Wolf, Dominik
AU - Çolak, Gökçe Melis
AU - García-Sanz, Ramón
AU - Emarah, Ziad
AU - Mišković, Bojana
AU - Gräfe, Stefanie K.
AU - Mladenović, Miloš
AU - Aiello, Tommaso Francesco
AU - Núñez-Martín-Buitrago, Lucía
AU - Nordlander, Anna
AU - Arellano, Elena
AU - Zambrotta, Giovanni Paolo Maria
AU - Ammatuna, Emanuele
AU - Cabirta, Alba
AU - Sacchi, Maria Vittoria
AU - Rodrigues, Raquel Nunes
AU - Hersby, Ditte Stampe
AU - Hanakova, Michaela
AU - Rahimli, Laman
AU - Cordoba, Raul
AU - Cornely, Oliver A.
AU - Pagano, Livio
AU - Marques De Almeida, Joyce
AU - Hernández-Rivas, José Ángel
AU - Guidetti, Anna
AU - Finizio, Olimpia
AU - Stojanoski, Zlate
AU - Cvetanoski, Milche
AU - Meletiadis, Joseph
AU - de Jonge, Nick
AU - Antić, Darko
AU - Ali, Natasha
AU - Tisi, Maria Chiara
AU - Serrano, Laura
AU - Plantefeve, Gaëtan
AU - Khanna, Nina
AU - Hoenigl, Martin
AU - Čerňan, Martin
AU - Miranda-Castillo, Carolina
AU - Fernández-Galán, María
AU - Ser-Ris, Alexandra
AU - Erben, Nurettin
AU - Duléry, Rémy
AU - Aujayeb, Avinash
AU - Papa, Mario Virgilio
AU - Novák, Jan
AU - Delia, Mario
AU - Sapienza, Giuseppe
AU - Reizine, Florian
AU - Omrani, Ali S.
AU - Di Blasi, Roberta
AU - Lamure, Sylvain
AU - Drgoňa, Ľuboš
AU - Coppola, Nicola
AU - Batinić, Josip
AU - Al-Khabori, Murtadha
AU - Ribera-Santa Susana, José María
AU - Piedimonte, Monica
AU - Loureiro-Amigo, Jorge
AU - Fouquet, Guillemette
AU - Fazzi, Rita
AU - Danion, François
AU - Schubert, Jörg
AU - Hoell-Neugebauer, Baerbel
AU - Bahr, Nathan C.
AU - Yahia, Ayel Omar
AU - Torres-Atienza, Ana
AU - Rinaldi, Ikhwan
AU - Popova, Marina
AU - Ommen, Hans Beier
AU - Mitra, Maria Enza
AU - Mikulska, Malgorzata
AU - Lacej, Ira
AU - Khostelidi, Sofya
AU - Win, Sein
AU - Vinh, Donald
AU - Saleh, Modar
AU - Prattes, Juergen
AU - Jindra, Pavel
AU - Guolo, Fabio
AU - della Pepa, Roberta
AU - Chelysheva, Ekaterina
AU - Zdziarski, Przemyslaw
AU - Wai-Man, Vivien
AU - Soto-Silva, Andrés
AU - Orth, Hans Martin
AU - Malak, Sandra
AU - Lorenzo De La Peña, Lisset
AU - Kolditz, Martin
AU - Kho, Chi Shan
AU - Heath, Christopher H.
AU - Groh, Ana
AU - Gavriilaki, Eleni
AU - Fung, Monica
AU - Egger, Matthias
AU - de Kort, Elizabeth
AU - de Cabo, Erik
AU - Cushion, Tania
AU - Chowdhury, Fazle Rabbi
AU - Ceesay, M. Mansour
AU - Brehon, Mathias
AU - Varricchio, Gina
AU - Tafuri, Agostino
AU - Jiménez-Lorenzo, María Josefa
AU - Klimko, Nikolai
AU - Tsirigotis, Panagiotis
AU - Antoniadou, Anastasia
AU - Vehreschild, Maria
N1 - Publisher Copyright: © 2023 The Author(s)
PY - 2023
Y1 - 2023
N2 - Objectives: Elderly patients with hematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection's impact on different age groups remains unstudied in detail. Methods: We analyzed elderly patients (age groups: 65-70, 71-75, 76-80, and >80 years old) with hematologic malignancies included in the EPICOVIDEHA registry between January 2020 and July 2022. Univariable and multivariable Cox regression models were conducted to identify factors influencing death in COVID-19 patients with hematological malignancy. Results: The study included data from 3,603 elderly patients (aged 65 or older) with hematological malignancy, with a majority being male (58.1%) and a significant proportion having comorbidities. The patients were divided into four age groups, and the analysis assessed COVID-19 outcomes, vaccination status, and other variables in relation to age and pandemic waves. The 90-day survival rate for patients with COVID-19 was 71.2%, with significant differences between groups. The pandemic waves had varying impacts, with the first wave affecting patients over 80 years old, the second being more severe in 65-70, and the third being the least severe in all age groups. Factors contributing to 90-day mortality included age, comorbidities, lymphopenia, active malignancy, acute leukemia, less than three vaccine doses, severe COVID-19, and using only corticosteroids as treatment. Conclusion: These data underscore the heterogeneity of elderly hematological patients, highlight the different impacts of COVID-19 waves and the pivotal importance of vaccination, and may help in planning future healthcare efforts.
AB - Objectives: Elderly patients with hematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection's impact on different age groups remains unstudied in detail. Methods: We analyzed elderly patients (age groups: 65-70, 71-75, 76-80, and >80 years old) with hematologic malignancies included in the EPICOVIDEHA registry between January 2020 and July 2022. Univariable and multivariable Cox regression models were conducted to identify factors influencing death in COVID-19 patients with hematological malignancy. Results: The study included data from 3,603 elderly patients (aged 65 or older) with hematological malignancy, with a majority being male (58.1%) and a significant proportion having comorbidities. The patients were divided into four age groups, and the analysis assessed COVID-19 outcomes, vaccination status, and other variables in relation to age and pandemic waves. The 90-day survival rate for patients with COVID-19 was 71.2%, with significant differences between groups. The pandemic waves had varying impacts, with the first wave affecting patients over 80 years old, the second being more severe in 65-70, and the third being the least severe in all age groups. Factors contributing to 90-day mortality included age, comorbidities, lymphopenia, active malignancy, acute leukemia, less than three vaccine doses, severe COVID-19, and using only corticosteroids as treatment. Conclusion: These data underscore the heterogeneity of elderly hematological patients, highlight the different impacts of COVID-19 waves and the pivotal importance of vaccination, and may help in planning future healthcare efforts.
KW - COVID-19
KW - Elderly
KW - Hematological malignancy
KW - High-risk patient
KW - SARS-CoV-2
U2 - 10.1016/j.ijid.2023.10.013
DO - 10.1016/j.ijid.2023.10.013
M3 - Journal article
C2 - 37863310
AN - SCOPUS:85176106626
VL - 137
SP - 98
EP - 110
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
SN - 1201-9712
ER -