@article{e269f46054a311dd8d9f000ea68e967b,
title = "Akt and 14-3-3eta regulate Miz1 to control cell-cycle arrest after DNA damage.",
abstract = "The transcription factor Miz1 is required for DNA-damage-induced cell-cycle arrest. We have now identified 14-3-3eta as a gene that inhibits Miz1 function through interaction with its DNA binding domain. Binding of 14-3-3eta to Miz1 depends on phosphorylation by Akt and regulates the recovery of cells from arrest after DNA damage. Miz1 has two functions in response to DNA damage: first, it is required for upregulation of a large group of genes, a function that is regulated by c-Myc, but not by 14-3-3eta; second, Miz1 represses the expression of many genes in response to DNA damage in an Akt- and 14-3-3eta-regulated manner.",
author = "Michael Wanzel and Daniela Kleine-Kohlbrecher and Steffi Herold and Andreas Hock and Katrien Berns and Jongsun Park and Brian Hemmings and Martin Eilers",
note = "Keywords: 14-3-3 Proteins; Animals; Cell Cycle; Cell Cycle Proteins; DNA Damage; DNA-Binding Proteins; Gene Expression Regulation; Gene Library; Hela Cells; Humans; Kruppel-Like Transcription Factors; Mice; Molecular Sequence Data; NIH 3T3 Cells; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Protein-Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Rats; Transcription Factors; Up-Regulation",
year = "2004",
doi = "10.1038/ncb1202",
language = "English",
volume = "7",
pages = "30--41",
journal = "Nature Cell Biology",
issn = "1465-7392",
publisher = "nature publishing group",
number = "1",
}