Abstract
Alpha-cyclodextrin (α-CD) is a non-absorbable and soluble fiber that causes weight loss. We studied whether this is due to an effect on GLP-1 secretion. In GLUTag cells, α-CD increased GLP-1 secretion up to 170% via adenylyl cyclase, phospholipase C, and L-type calcium channels dependent processes. In rat isolated colon perfusions, luminal α-CD increased GLP-1 secretion with 20%. In lean mice, once daily α-CD versus saline caused weight loss and lowered the peak in glucose after an oral glucose tolerance test (OGTT). In obese mice, α-CD added to high-fat diet caused weight loss similar to the control group (receiving cellulose). However, compared to cellulose, the α-CD group ate less. During an OGTT, no differences were observed in glucose, insulin and GLP-1. Thus, α-CD increases GLP-1 secretion in a dose-dependent manner and could be a safe and easy addition to food products to help reduce body weight.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 140759 |
| Tidsskrift | Food Chemistry |
| Vol/bind | 460 |
| Antal sider | 10 |
| ISSN | 0308-8146 |
| DOI | |
| Status | Udgivet - 2024 |
Bibliografisk note
Funding Information:MMR received funding from the Independent Research Fund Denmark, Medical Sciences (grant no. 9039-00298B), The Novo Nordisk Foundation (grant no. NNF17OC0027248), The Lundbeck Foundation (R268\u20132017-409), The European Research Council, ERC (CoG 682549), a Donation from deceased Valter Alex Torbj\u00F8rn Eichmuller (VAT Eichmuller)-2020\u2013117043, and the Faculty of Health and Medical Sciences, University of Copenhagen covering running costs salaries for LV, EEB, AOB.
Funding Information:
The study was supported by an unrestricted grant to JJH from The Novo Nordisk Foundation Center for Basic Metabolic Research (NNF18CC0034900).
Publisher Copyright:
© 2024 The Authors