@article{100ac3e074c211dbbee902004c4f4f50,
title = "Alpha-MSH decreases core and brain temperature during global cerebral ischemia in rats",
abstract = "A key pathological event during cerebral ischemia is the excitotoxic release of glutamate. We have shown previously that alpha-melanocyte-stimulating hormone (alpha-MSH) enhances the hypothermia induced by kainic acid. We have investigated the effects of systemic administration of alpha-MSH on four-vessel occlusion forebrain ischemia on core temperature (CT) and brain temperature (BT), respectively. After 10 min cerebral ischemia, BT was lower in alpha-MSH- than in saline-injected animals. After 10 min reperfusion, both CT and BT were lower than the corresponding pre-ischemic levels after injection of alpha-MSH. alpha-MSH did not influence CT or BT in sham-operated rats. The alpha-MSH-induced hypothermia and its potentiation of reduction in BT during global cerebral ischemia, may contribute to neuroprotective effects of alpha-MSH.",
author = "S. Spulber and Mihai Moldovan and M. Oprica and A.F. Aronsson and C. Post and B. Winblad and M. Schultzberg",
note = "Keywords: Animals; Body Temperature; Brain; Ischemic Attack, Transient; Kinetics; Male; Rats; Rats, Sprague-Dawley; Reference Values; alpha-MSH",
year = "2005",
language = "English",
volume = "16",
pages = "69--72",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams & Wilkins",
number = "1",
}