Analysis of interaction between TGF and the myogenic response in renal blood flow autoregulation.

R Feldberg; M Colding-Jørgensen; N H Holstein-Rathlou

Analysis of interaction between TGF and the myogenic response in renal blood flow autoregulation.

R Feldberg, M Colding-Jørgensen, N H Holstein-Rathlou

Biomedicinsk Institut

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Udgivelsesdato: 1995-Oct

Originalsprog	Engelsk
Tidsskrift	American Journal of Physiology (Consolidated)
Vol/bind	269
Udgave nummer	4 Pt 2
Sider (fra-til)	F581-93
ISSN	0002-9513
Status	Udgivet - 1995

Bibliografisk note

Keywords: Animals; Arterioles; Feedback; Homeostasis; Kidney Glomerulus; Kidney Tubules; Models, Cardiovascular; Muscle, Smooth, Vascular; Pressure; Rats; Renal Circulation; Vascular Resistance; Vasoconstriction

Citationsformater

@article{b6958760abeb11ddb5e9000ea68e967b,

title = "Analysis of interaction between TGF and the myogenic response in renal blood flow autoregulation.",

abstract = "The present study investigates the interaction between the tubuloglomerular feedback (TGF) response and the myogenic mechanism by use of a mathematical model. The two control mechanisms are implemented in a spatially distributed model of the rat renal juxtamedullary afferent arteriole. The model of the afferent arteriole is based on in vivo measurements of the stress-strain relation in muscle strips. Analysis of experimental data shows that the myogenic response can be modeled by a linear relation between the transmural pressure and the level of activation of the vascular smooth muscle cells. The contribution of TGF to smooth muscle activity is assumed to be a linear function of the glomerular capillary pressure. The results show that the myogenic response plays an important role in renal blood flow autoregulation. Without a myogenic response, mechanisms such as TGF that are localized in the distal segments of the microvasculature would not be able to achieve autoregulation because of passive, pressure-mediated effects in the upstream vascular segments. In addition, it is shown that a strong myogenic response may lead to both propagation and enhancement of vascular effects mediated through mechanisms located in the distal part of the afferent arteriole. An ascending myogenic response could enhance the regulatory efficiency of the TGF mechanism by increasing the open-loop gain of the system. However, such a synergistic interaction will only be observed when the two mechanisms operate on more or less separate segments of the afferent arteriole. In the case where they operate on common segments of the arteriole, the outcome of the interaction may well be antagonistic.",

author = "R Feldberg and M Colding-J{\o}rgensen and Holstein-Rathlou, {N H}",

note = "Keywords: Animals; Arterioles; Feedback; Homeostasis; Kidney Glomerulus; Kidney Tubules; Models, Cardiovascular; Muscle, Smooth, Vascular; Pressure; Rats; Renal Circulation; Vascular Resistance; Vasoconstriction",

year = "1995",

language = "English",

volume = "269",

pages = "F581--93",

journal = "American Journal of Physiology - Cell Physiology",

issn = "0363-6143",

publisher = "American Physiological Society",

number = "4 Pt 2",

}

TY - JOUR

T1 - Analysis of interaction between TGF and the myogenic response in renal blood flow autoregulation.

AU - Feldberg, R

AU - Colding-Jørgensen, M

AU - Holstein-Rathlou, N H

N1 - Keywords: Animals; Arterioles; Feedback; Homeostasis; Kidney Glomerulus; Kidney Tubules; Models, Cardiovascular; Muscle, Smooth, Vascular; Pressure; Rats; Renal Circulation; Vascular Resistance; Vasoconstriction

PY - 1995

Y1 - 1995

N2 - The present study investigates the interaction between the tubuloglomerular feedback (TGF) response and the myogenic mechanism by use of a mathematical model. The two control mechanisms are implemented in a spatially distributed model of the rat renal juxtamedullary afferent arteriole. The model of the afferent arteriole is based on in vivo measurements of the stress-strain relation in muscle strips. Analysis of experimental data shows that the myogenic response can be modeled by a linear relation between the transmural pressure and the level of activation of the vascular smooth muscle cells. The contribution of TGF to smooth muscle activity is assumed to be a linear function of the glomerular capillary pressure. The results show that the myogenic response plays an important role in renal blood flow autoregulation. Without a myogenic response, mechanisms such as TGF that are localized in the distal segments of the microvasculature would not be able to achieve autoregulation because of passive, pressure-mediated effects in the upstream vascular segments. In addition, it is shown that a strong myogenic response may lead to both propagation and enhancement of vascular effects mediated through mechanisms located in the distal part of the afferent arteriole. An ascending myogenic response could enhance the regulatory efficiency of the TGF mechanism by increasing the open-loop gain of the system. However, such a synergistic interaction will only be observed when the two mechanisms operate on more or less separate segments of the afferent arteriole. In the case where they operate on common segments of the arteriole, the outcome of the interaction may well be antagonistic.

AB - The present study investigates the interaction between the tubuloglomerular feedback (TGF) response and the myogenic mechanism by use of a mathematical model. The two control mechanisms are implemented in a spatially distributed model of the rat renal juxtamedullary afferent arteriole. The model of the afferent arteriole is based on in vivo measurements of the stress-strain relation in muscle strips. Analysis of experimental data shows that the myogenic response can be modeled by a linear relation between the transmural pressure and the level of activation of the vascular smooth muscle cells. The contribution of TGF to smooth muscle activity is assumed to be a linear function of the glomerular capillary pressure. The results show that the myogenic response plays an important role in renal blood flow autoregulation. Without a myogenic response, mechanisms such as TGF that are localized in the distal segments of the microvasculature would not be able to achieve autoregulation because of passive, pressure-mediated effects in the upstream vascular segments. In addition, it is shown that a strong myogenic response may lead to both propagation and enhancement of vascular effects mediated through mechanisms located in the distal part of the afferent arteriole. An ascending myogenic response could enhance the regulatory efficiency of the TGF mechanism by increasing the open-loop gain of the system. However, such a synergistic interaction will only be observed when the two mechanisms operate on more or less separate segments of the afferent arteriole. In the case where they operate on common segments of the arteriole, the outcome of the interaction may well be antagonistic.

M3 - Journal article

C2 - 7485545

VL - 269

SP - F581-93

JO - American Journal of Physiology - Cell Physiology

JF - American Journal of Physiology - Cell Physiology

SN - 0363-6143

IS - 4 Pt 2

ER -