TY - JOUR
T1 - Anthropometry, DXA and leptin reflect subcutaneous but not visceral abdominal adipose tissue by MRI in 197 healthy adolescents
AU - Tinggaard, Jeanette
AU - Hagen, Casper P
AU - Christensen, Anders N
AU - Mouritsen, Annette
AU - Mieritz, Mikkel G
AU - Wohlfahrt-Veje, Christine
AU - Helge, Jørn W
AU - Beck, Thomas N
AU - Fallentin, Eva
AU - Larsen, Rasmus
AU - Jensen, Rikke B
AU - Juul, Anders
AU - Main, Katharina M
PY - 2017
Y1 - 2017
N2 - BACKGROUND: Abdominal fat distribution is associated with development of cardio-metabolic disease, independently of BMI. We assessed anthropometry, serum adipokines and DXA as markers of abdominal subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) by MRIMETHODS:We performed a cross-sectional study including 197 healthy adolescents (114 boys) aged 10-15 years nested within a longitudinal population-based cohort. Clinical examination, blood sampling, DXA and abdominal MRI was performed. SAT% and VAT% was adjusted to total abdominal volume.RESULTS: Girls had a higher SAT% than boys in early and late puberty (16 vs. 13%, P<0.01 and 20 vs. 15%, P=0.001, respectively), whereas VAT% was comparable (7% in both genders, independent of puberty). DXA android fat% (Standard Deviation Score [SDS]), suprailliac skinfold thickness (SDS), leptin, BMI (SDS), waist-to-height ratio (WHtR) and waist circumference (SDS) correlated strongly with SAT% (descending order: r=0.90 to r=0.55, all P<0.001), but weaker to VAT% (r=0.49 to r=0.06). Suprailiac skinfold was the best anthropometric marker of SAT% (girls: R(2)=48.6%, boys: R(2)=65.0%, P<0.001) and VAT% in boys (R(2)=16.4%, P<0.001). WHtR was the best marker of VAT% in girls (R(2)=7.6%, P=0.007).CONCLUSIONS: Healthy girls have a higher SAT% than boys, whereas VAT% is comparable, independent of puberty. Anthropometry and circulating leptin are valid markers of SAT%, but not VAT%.Pediatric Research accepted article preview online, 12 June 2017. doi:10.1038/pr.2017.138.
AB - BACKGROUND: Abdominal fat distribution is associated with development of cardio-metabolic disease, independently of BMI. We assessed anthropometry, serum adipokines and DXA as markers of abdominal subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) by MRIMETHODS:We performed a cross-sectional study including 197 healthy adolescents (114 boys) aged 10-15 years nested within a longitudinal population-based cohort. Clinical examination, blood sampling, DXA and abdominal MRI was performed. SAT% and VAT% was adjusted to total abdominal volume.RESULTS: Girls had a higher SAT% than boys in early and late puberty (16 vs. 13%, P<0.01 and 20 vs. 15%, P=0.001, respectively), whereas VAT% was comparable (7% in both genders, independent of puberty). DXA android fat% (Standard Deviation Score [SDS]), suprailliac skinfold thickness (SDS), leptin, BMI (SDS), waist-to-height ratio (WHtR) and waist circumference (SDS) correlated strongly with SAT% (descending order: r=0.90 to r=0.55, all P<0.001), but weaker to VAT% (r=0.49 to r=0.06). Suprailiac skinfold was the best anthropometric marker of SAT% (girls: R(2)=48.6%, boys: R(2)=65.0%, P<0.001) and VAT% in boys (R(2)=16.4%, P<0.001). WHtR was the best marker of VAT% in girls (R(2)=7.6%, P=0.007).CONCLUSIONS: Healthy girls have a higher SAT% than boys, whereas VAT% is comparable, independent of puberty. Anthropometry and circulating leptin are valid markers of SAT%, but not VAT%.Pediatric Research accepted article preview online, 12 June 2017. doi:10.1038/pr.2017.138.
KW - Journal Article
U2 - 10.1038/pr.2017.138
DO - 10.1038/pr.2017.138
M3 - Journal article
C2 - 28604756
VL - 82
SP - 620
EP - 628
JO - Pediatric Research
JF - Pediatric Research
SN - 0031-3998
ER -