Anti-phosphatidylserine antibody levels are low in multigravid pregnant women in a malaria-endemic area in Nigeria, and do not correlate with anti-VAR2CSA antibodies

Adebimpe Fasanya, Nurat Mohammed, Bandar Hasan Saleh, Muyideen Kolapo Tijani, Alexandra Teleka, Maria Del Pilar Quintana, Lars Hviid, Kristina E M Persson

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Abstract

Anemia is a common malaria-associated complication in pregnant women in endemic regions. Phosphatidylserine (PS) is exposed to the immune system during the massive destruction of red blood cells (RBCs) that accompany malaria, and antibodies against PS have been linked to anemia through destruction of uninfected RBCs. We determined levels of anti-PS IgG antibodies in pregnant women in Ibadan, Nigeria and correlated them to parameters of importance in development of anemia and immunity. Anti-PS correlated inversely with Packed Cell Volume (PCV), indicating that the antibodies could contribute to anemia. There was no correlation with anti-VAR2CSA IgG, haptoglobin or parasitemia, indicating that the modulation of anti-PS response is multifactorial in nature. Anti-PS levels were lowest in multigravidae compared to both primigravidae and secundigravidae and correlated inversely with age. In conclusion, lower levels of anti-PS in multigravidae could be beneficial in avoiding anemia.

OriginalsprogEngelsk
Artikelnummer1130186
TidsskriftFrontiers in Cellular and Infection Microbiology
Vol/bind13
ISSN2235-2988
DOI
StatusUdgivet - 2023

Bibliografisk note

Copyright © 2023 Fasanya, Mohammed, Saleh, Tijani, Teleka, Quintana, Hviid and Persson.

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