Antiinflammatory and neurological activity of pyrithione and related sulfur-containing pyridine N-oxides from Persian shallot (Allium stipitatum)

Petra Krejčová, Petra Kučerová, Gary Ivan Stafford, Anna Jäger, Roman Kubec

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

33 Citationer (Scopus)

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE: Persian shallot (Allium stipitatum) is a bulbous plant native to Turkey, Iran and Central Asia. It is frequently used in folk medicine for the treatment of a variety of disorders, including inflammation and stress. Antiinflammatory and neurological activities of pyrithione and four related sulfur-containing pyridine N-oxides which are prominent constituents of Allium stipitatum were tested.

METHODS: The antiinflammatory activity was tested by the ability of the compounds to inhibit cyclooxygenase (COX-1 and COX-2), whereas the neurological activities were evaluated by assessing the compounds ability to inhibit monoamine oxidase-A (MAO-A) and acetylcholinesterase (AChE). The compounds׳ affinity for the serotonin transport protein (SERT) and the GABAA-benzodiazepine receptor were also investigated.

RESULTS: 2-[(Methylthio)methyldithio]pyridine N-oxide showed very high antiinflammatory effects which are comparable with those of common pharmaceuticals (IC50 of 7.8 and 15.4µM for COX-1 and COX-2, respectively). On the other hand, neurological activities of the compounds were rather modest. Some compounds moderately inhibited AChE (IC50 of 104-1041µM) and MAO-A (IC50 of 98-241µM) and exhibited an affinity for the SERT and GABAA-benzodiazepine receptor.

CONCLUSIONS: Our findings may help to rationalize the wide use of Persian shallot for the treatment of inflammatory disorders.

OriginalsprogEngelsk
TidsskriftJournal of Ethnopharmacology
Vol/bind154
Udgave nummer1
Sider (fra-til)176-182
Antal sider7
ISSN0378-8741
DOI
StatusUdgivet - 2014

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