Abstract
Aglepristone is an antiprogestin that acts as a full progesterone receptor antagonist and therefore administration induces abolition of progesterone effects. Although the on-labelindication is termination of pregnancy in bitches up to 45 days after mating/LH peak only, there are various other off-label indications where its use has been successfully described. These include termination of pregnancy in queens and rabbits, induction of parturition in bitches, medical treatment of pyometra in bitches, queens, hamsters and guinea pigs and treatment of fibroadenomatosis. Additionally successful use has been described for gestagen-dependent insulin resistant diabetes mellitus, acromegaly in bitches, size reduction of benign canine vaginal tumours and reduction of proliferation of progesterone-receptor expressing mammary carcinomas. This review aims to give an update on possibilities and indicates limitations of the described use.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Turkiye Klinikleri Journal of Veterinary Sciences-Surgery-Special Topics |
| Vol/bind | 3 |
| Udgave nummer | 1 |
| Sider (fra-til) | 24-31 |
| Antal sider | 8 |
| ISSN | 2149-5343 |
| Status | Udgivet - 2017 |