Abstract
Aims
The prevalence and difference in risk factors for having thoracic aortic aneurysm (TAA) and abdominal aortic aneurysm (AAA) in men compared with women in the general population is not well described. This study aimed to test the hypotheses that (i) cardiovascular risk factors for TAA and AAA differ and (ii) the prevalence of TAA and AAA is sex specific.
Methods and results
Aortic examination using computed tomography angiography was performed in 11 294 individuals (56% women), with a mean age of 62 (range 40–95) years participating in the Copenhagen General Population Study. TAAs were defined as an ascending aortic diameter ≥45 mm and a descending aortic diameter ≥35 mm, while AAAs were defined as an abdominal aortic diameter ≥30 mm. Demographic data were obtained from questionnaires. Overall prevalence of aortic aneurysms (AAs) in the study population included: total population 2.1%, men 4.0% and women 0.7% (P-value men vs. women P < 0.001). AAs were independently associated with male sex, increasing age, and body surface area (BSA). While TAAs were associated with hypertension, odds ratio (OR) = 2.0 [95% confidence interval (CI): 1.5–2.8], AAAs were associated with hypercholesterolaemia and smoking, OR = 2.4 (95% CI: 1.6–3.6) and 3.2 (95% CI: 1.9–5.4).
Conclusion
Subclinical AAs are four times more prevalent in men than in women. In both sexes, increasing age and BSA are risk factors for AAs of any anatomical location. Whereas arterial hypertension is a risk factor for TAAs, hypercholesterolaemia and smoking are risk factors for AAAs.
The prevalence and difference in risk factors for having thoracic aortic aneurysm (TAA) and abdominal aortic aneurysm (AAA) in men compared with women in the general population is not well described. This study aimed to test the hypotheses that (i) cardiovascular risk factors for TAA and AAA differ and (ii) the prevalence of TAA and AAA is sex specific.
Methods and results
Aortic examination using computed tomography angiography was performed in 11 294 individuals (56% women), with a mean age of 62 (range 40–95) years participating in the Copenhagen General Population Study. TAAs were defined as an ascending aortic diameter ≥45 mm and a descending aortic diameter ≥35 mm, while AAAs were defined as an abdominal aortic diameter ≥30 mm. Demographic data were obtained from questionnaires. Overall prevalence of aortic aneurysms (AAs) in the study population included: total population 2.1%, men 4.0% and women 0.7% (P-value men vs. women P < 0.001). AAs were independently associated with male sex, increasing age, and body surface area (BSA). While TAAs were associated with hypertension, odds ratio (OR) = 2.0 [95% confidence interval (CI): 1.5–2.8], AAAs were associated with hypercholesterolaemia and smoking, OR = 2.4 (95% CI: 1.6–3.6) and 3.2 (95% CI: 1.9–5.4).
Conclusion
Subclinical AAs are four times more prevalent in men than in women. In both sexes, increasing age and BSA are risk factors for AAs of any anatomical location. Whereas arterial hypertension is a risk factor for TAAs, hypercholesterolaemia and smoking are risk factors for AAAs.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | European Heart Journal Cardiovascular Imaging |
| Vol/bind | 25 |
| Udgave nummer | 9 |
| Sider (fra-til) | 1235-1243 |
| Antal sider | 9 |
| ISSN | 2047-2404 |
| DOI | |
| Status | Udgivet - 2024 |
Bibliografisk note
Funding Information:Conflict of interest: M.H.C.P. has received a research grant from the Research Council of Rigshospitalet. K.F.K. has received research grants from AP M\u00F8ller og Hustru Chastine McKinney M\u00F8llers Fond, the John and Birthe Meyer Foundation, the Research Council of Rigshospitalet, the University of Copenhagen, the Danish Heart Foundation, the Lundbeck Foundation, the Danish Agency for Science, Technology and Innovation by the Danish Council for Strategic Research, and the Novo Nordisk Foundation and is on the Speakers Bureau of Canon Medical Systems. P.E.S. reports consulting fees from Novo Nordisk A/S outside the submitted work. L.V.K. has received research grants from the Danish Research Council. The remaining authors declare no conflict of interest.
Funding Information:
This study was funded by AP M\u00F8ller og Hustru Chastine McKinney M\u00F8llers Fond and Rigshospitalet.
Publisher Copyright:
© 2024 The Author(s).