@article{d0a3aeb48c9441d2ba7293510fff8fba,
title = "Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL",
abstract = "Oxidation of LDL plays a key role in the development of atherosclerosis. HDL may, in part, protect against atherosclerosis by inhibiting LDL oxidation. Overexpression of HDL-associated apolipoprotein M (apoM) protects mice against atherosclerosis through a not yet clarified mechanism. Being a lipocalin, apoM contains a binding pocket for small lipophilic molecules. Here, we report that apoM likely serves as an antioxidant in HDL by binding oxidized phospholipids, thus enhancing the antioxidant potential of HDL.",
keywords = "Amidines, Animals, Antioxidants, Apolipoproteins, Atherosclerosis, Binding Sites, Cholesterol, Dietary, Disease Models, Animal, Humans, Lipocalins, Lipoproteins, HDL, Lipoproteins, LDL, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Myristic Acid, Oxidants, Oxidation-Reduction, Phospholipids, Receptors, LDL, Recombinant Proteins, Thiobarbituric Acid Reactive Substances, Time Factors",
author = "Sara Els{\o}e and Josefin Ahnstr{\"o}m and Christina Christoffersen and Hoofnagle, {Andrew N} and Peter Plomgaard and Heinecke, {Jay W} and Binder, {Christoph J} and Harry Bj{\"o}rkbacka and Bj{\"o}rn Dahlb{\"a}ck and Nielsen, {Lars Bo}",
note = "Copyright {\^A}{\textcopyright} 2011 Elsevier Ireland Ltd. All rights reserved.",
year = "2012",
doi = "10.1016/j.atherosclerosis.2011.11.031",
language = "English",
volume = "221",
pages = "91--7",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "1",
}