Applications of terahertz pulsed imaging to sustained-release tablet film coating quality assessment and dissolution performance

Louise Ho, Ronny Müller, Keith C Gordon, Peter Kleinebudde, Michael Pepper, Thomas Rades, Yaochun Shen, Philip F Taday, J Axel Zeitler

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

91 Citationer (Scopus)

Abstract

The potential of terahertz pulsed imaging (TPI) to predict the dissolution performance in sustained-release tablets was investigated in this study. Batches of coated tablets with similar weight gain during the coating process at the lab and pilot scales were subjected to non-destructive imaging by TPI and subsequently analysed by dissolution testing. The results from the dissolution tests revealed significant differences in the product performance between the lab and pilot scales (Student t-test, P
OriginalsprogEngelsk
TidsskriftJournal of controlled release : official journal of the Controlled Release Society
Vol/bind127
Udgave nummer1
Sider (fra-til)79-87
Antal sider9
DOI
StatusUdgivet - 2008
Udgivet eksterntJa

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