Are left ventricular mass, geometry and function related to vascular changes and/or insulin resistance in long-standing hypertension? ICARUS: a LIFE substudy

M H Olsen; E Hjerkinn; K Wachtell; A Høieggen; J N Bella; S D Nesbitt; E Fossum; S E Kjeldsen; S Julius; H Ibsen; H Ibsen

doi:10.1038/sj.jhh.1001545

Are left ventricular mass, geometry and function related to vascular changes and/or insulin resistance in long-standing hypertension? ICARUS: a LIFE substudy

M H Olsen, E Hjerkinn, K Wachtell, A Høieggen, J N Bella, S D Nesbitt, E Fossum, S E Kjeldsen, S Julius, H Ibsen, H Ibsen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

13 Citationer (Scopus)

Abstract

Vascular hypertrophy and insulin resistance have been associated with abnormal left ventricular (LV) geometry in population studies. We wanted to investigate the influence of vascular hypertrophy and insulin resistance on LV hypertrophy and its function in patients with hypertension. In 89 patients with essential hypertension and electrocardiographic LV hypertrophy, we measured blood pressure; insulin sensitivity by hyperinsulinaemic euglucaemic clamp; minimal forearm vascular resistance (MFVR) by plethysmography; intima-media cross-sectional area of the common carotid arteries (IMA) by ultrasound; and LV mass, relative wall thickness (RWT), systolic function and diastolic filling by echocardiography after two weeks of placebo treatment. LV mass index correlated to IMA/height (r=0.36, P=0.001), serum insulin (r=-0.25, P

Originalsprog	Engelsk
Tidsskrift	Journal of Human Hypertension
Vol/bind	17
Udgave nummer	5
Sider (fra-til)	305-11
Antal sider	7
ISSN	0950-9240
DOI	https://doi.org/10.1038/sj.jhh.1001545
Status	Udgivet - 2003

Adgang til dokumentet

10.1038/sj.jhh.1001545

Citationsformater

Olsen, M. H., Hjerkinn, E., Wachtell, K., Høieggen, A., Bella, J. N., Nesbitt, S. D., Fossum, E., Kjeldsen, S. E., Julius, S., Ibsen, H., & Ibsen, H. (2003). Are left ventricular mass, geometry and function related to vascular changes and/or insulin resistance in long-standing hypertension? ICARUS: a LIFE substudy. Journal of Human Hypertension, 17(5), 305-11. https://doi.org/10.1038/sj.jhh.1001545

Olsen, MH, Hjerkinn, E, Wachtell, K, Høieggen, A, Bella, JN, Nesbitt, SD, Fossum, E, Kjeldsen, SE, Julius, S, Ibsen, H & Ibsen, H 2003, 'Are left ventricular mass, geometry and function related to vascular changes and/or insulin resistance in long-standing hypertension? ICARUS: a LIFE substudy', Journal of Human Hypertension, bind 17, nr. 5, s. 305-11. https://doi.org/10.1038/sj.jhh.1001545

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title = "Are left ventricular mass, geometry and function related to vascular changes and/or insulin resistance in long-standing hypertension? ICARUS: a LIFE substudy",

abstract = "Vascular hypertrophy and insulin resistance have been associated with abnormal left ventricular (LV) geometry in population studies. We wanted to investigate the influence of vascular hypertrophy and insulin resistance on LV hypertrophy and its function in patients with hypertension. In 89 patients with essential hypertension and electrocardiographic LV hypertrophy, we measured blood pressure; insulin sensitivity by hyperinsulinaemic euglucaemic clamp; minimal forearm vascular resistance (MFVR) by plethysmography; intima-media cross-sectional area of the common carotid arteries (IMA) by ultrasound; and LV mass, relative wall thickness (RWT), systolic function and diastolic filling by echocardiography after two weeks of placebo treatment. LV mass index correlated to IMA/height (r=0.36, P=0.001), serum insulin (r=-0.25, P",

author = "Olsen, {M H} and E Hjerkinn and K Wachtell and A H{\o}ieggen and Bella, {J N} and Nesbitt, {S D} and E Fossum and Kjeldsen, {S E} and S Julius and H Ibsen and H Ibsen",

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doi = "10.1038/sj.jhh.1001545",

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T1 - Are left ventricular mass, geometry and function related to vascular changes and/or insulin resistance in long-standing hypertension? ICARUS: a LIFE substudy

AU - Olsen, M H

AU - Hjerkinn, E

AU - Wachtell, K

AU - Høieggen, A

AU - Bella, J N

AU - Nesbitt, S D

AU - Fossum, E

AU - Kjeldsen, S E

AU - Julius, S

AU - Ibsen, H

PY - 2003

Y1 - 2003

N2 - Vascular hypertrophy and insulin resistance have been associated with abnormal left ventricular (LV) geometry in population studies. We wanted to investigate the influence of vascular hypertrophy and insulin resistance on LV hypertrophy and its function in patients with hypertension. In 89 patients with essential hypertension and electrocardiographic LV hypertrophy, we measured blood pressure; insulin sensitivity by hyperinsulinaemic euglucaemic clamp; minimal forearm vascular resistance (MFVR) by plethysmography; intima-media cross-sectional area of the common carotid arteries (IMA) by ultrasound; and LV mass, relative wall thickness (RWT), systolic function and diastolic filling by echocardiography after two weeks of placebo treatment. LV mass index correlated to IMA/height (r=0.36, P=0.001), serum insulin (r=-0.25, P

AB - Vascular hypertrophy and insulin resistance have been associated with abnormal left ventricular (LV) geometry in population studies. We wanted to investigate the influence of vascular hypertrophy and insulin resistance on LV hypertrophy and its function in patients with hypertension. In 89 patients with essential hypertension and electrocardiographic LV hypertrophy, we measured blood pressure; insulin sensitivity by hyperinsulinaemic euglucaemic clamp; minimal forearm vascular resistance (MFVR) by plethysmography; intima-media cross-sectional area of the common carotid arteries (IMA) by ultrasound; and LV mass, relative wall thickness (RWT), systolic function and diastolic filling by echocardiography after two weeks of placebo treatment. LV mass index correlated to IMA/height (r=0.36, P=0.001), serum insulin (r=-0.25, P

U2 - 10.1038/sj.jhh.1001545

DO - 10.1038/sj.jhh.1001545

M3 - Journal article

SN - 0950-9240

VL - 17

SP - 305

EP - 311

JO - Journal of Human Hypertension

JF - Journal of Human Hypertension

IS - 5

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