Abstract
Objectives
This systematic review and meta-analysis aimed to assess the stroke detection performance of artificial intelligence (AI) in magnetic resonance imaging (MRI), and additionally to identify reporting insufficiencies.
Methods
PRISMA guidelines were followed. MEDLINE, Embase, Cochrane Central, and IEEE Xplore were searched for studies utilising MRI and AI for stroke detection. The protocol was prospectively registered with PROSPERO (CRD42021289748). Sensitivity, specificity, accuracy, and area under the receiver operating characteristic (ROC) curve were the primary outcomes. Only studies using MRI in adults were included. The intervention was AI for stroke detection with ischaemic and haemorrhagic stroke in separate categories. Any manual labelling was used as a comparator. A modified QUADAS-2 tool was used for bias assessment. The minimum information about clinical artificial intelligence modelling (MI-CLAIM) checklist was used to assess reporting insufficiencies. Meta-analyses were performed for sensitivity, specificity, and hierarchical summary ROC (HSROC) on low risk of bias studies.
Results
Thirty-three studies were eligible for inclusion. Fifteen studies had a low risk of bias. Low-risk studies were better for reporting MI-CLAIM items. Only one study examined a CE-approved AI algorithm. Forest plots revealed detection sensitivity and specificity of 93% and 93% with identical performance in the HSROC analysis and positive and negative likelihood ratios of 12.6 and 0.079.
Conclusion
Current AI technology can detect ischaemic stroke in MRI. There is a need for further validation of haemorrhagic detection. The clinical usability of AI stroke detection in MRI is yet to be investigated.
Critical relevance statement
This first meta-analysis concludes that AI, utilising diffusion-weighted MRI sequences, can accurately aid the detection of ischaemic brain lesions and its clinical utility is ready to be uncovered in clinical trials.
Key Points
There is a growing interest in AI solutions for detection aid.
The performance is unknown for MRI stroke assessment.
AI detection sensitivity and specificity were 93% and 93% for ischaemic lesions.
There is limited evidence for the detection of patients with haemorrhagic lesions.
AI can accurately detect patients with ischaemic stroke in MRI.
This systematic review and meta-analysis aimed to assess the stroke detection performance of artificial intelligence (AI) in magnetic resonance imaging (MRI), and additionally to identify reporting insufficiencies.
Methods
PRISMA guidelines were followed. MEDLINE, Embase, Cochrane Central, and IEEE Xplore were searched for studies utilising MRI and AI for stroke detection. The protocol was prospectively registered with PROSPERO (CRD42021289748). Sensitivity, specificity, accuracy, and area under the receiver operating characteristic (ROC) curve were the primary outcomes. Only studies using MRI in adults were included. The intervention was AI for stroke detection with ischaemic and haemorrhagic stroke in separate categories. Any manual labelling was used as a comparator. A modified QUADAS-2 tool was used for bias assessment. The minimum information about clinical artificial intelligence modelling (MI-CLAIM) checklist was used to assess reporting insufficiencies. Meta-analyses were performed for sensitivity, specificity, and hierarchical summary ROC (HSROC) on low risk of bias studies.
Results
Thirty-three studies were eligible for inclusion. Fifteen studies had a low risk of bias. Low-risk studies were better for reporting MI-CLAIM items. Only one study examined a CE-approved AI algorithm. Forest plots revealed detection sensitivity and specificity of 93% and 93% with identical performance in the HSROC analysis and positive and negative likelihood ratios of 12.6 and 0.079.
Conclusion
Current AI technology can detect ischaemic stroke in MRI. There is a need for further validation of haemorrhagic detection. The clinical usability of AI stroke detection in MRI is yet to be investigated.
Critical relevance statement
This first meta-analysis concludes that AI, utilising diffusion-weighted MRI sequences, can accurately aid the detection of ischaemic brain lesions and its clinical utility is ready to be uncovered in clinical trials.
Key Points
There is a growing interest in AI solutions for detection aid.
The performance is unknown for MRI stroke assessment.
AI detection sensitivity and specificity were 93% and 93% for ischaemic lesions.
There is limited evidence for the detection of patients with haemorrhagic lesions.
AI can accurately detect patients with ischaemic stroke in MRI.
Originalsprog | Engelsk |
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Artikelnummer | 160 |
Tidsskrift | Insights into Imaging |
Vol/bind | 15 |
Udgave nummer | 1 |
Antal sider | 13 |
ISSN | 1869-4101 |
DOI | |
Status | Udgivet - 2024 |
Bibliografisk note
Funding Information:DG received speaker honoraria from Pfizer and Bristol Myers Squibb outside the submitted work and participated in research outside the submitted work funded by Bayer with funds paid to the institution where he is employed. MN hold shares in Cerebriu. CHK received consulting fees from Cerebriu. CK is the local principal investigator in clinical trials initiated by Bayer. The authors JAB, MTE, OG, FSGH, MVS, MPB, and BSBR declare that they have no competing interests.
Publisher Copyright:
© The Author(s) 2024.