Assessing serum anti-nuclear antibodies HEp-2 patterns in synucleinopathies

Jonas Folke, Marie Skougaard, Trine Line Korsholm, Anne Line Strange Laursen, Lisette Salvesen, Anne Mette Hejl, Sara Bech, Annemette Løkkegaard, Tomasz Brudek, Sisse Bolm Ditlev, Susana Aznar*

*Corresponding author af dette arbejde

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Abstract

This study investigates the presence of antinuclear antibodies (ANA) in three primary synucleinopathies – Parkinson’s disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB), compared to healthy controls. Autoinflammatory disorders typically involve the immune system mistakenly attacking the body’s own cells and start producing ANA. There is an increasing body of evidence that immune-mediated inflammation is a pathological feature linked to synucleinopathies. To investigate whether this could be autoimmune mediated we analyzed for ANA in the plasma of 25 MSA, 25 PD, and 17 DLB patients, along with 25 healthy controls, using the ANA HEp-2 indirect immunofluorescence antibody assay (ANA HEp-2 IFA). Contrary to initial expectations, results showed ANA HEp-2 positivity in 12% of PD, 8% of MSA patients, 18% of DLB patients, and 17% of healthy controls, indicating no increased prevalence of ANA in synucleinopathies compared to age-matched healthy individuals. Various ANA HEp-2 patterns were identified, but no specific pattern was associated with individual synucleinopathies. We conclude hereby that synucleinopathies are not associated with detectable presence of ANA in plasma.
OriginalsprogEngelsk
Artikelnummer49
TidsskriftImmunity and Ageing
Vol/bind21
Udgave nummer1
Antal sider6
ISSN1742-4933
DOI
StatusUdgivet - 2024

Bibliografisk note

Funding Information:
Open access funding provided by Copenhagen University. Lundbeck Foundation (R400-2022-1103).

Publisher Copyright:
© The Author(s) 2024.

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