TY - JOUR
T1 - Assessment of endothelial function and myocardial flow reserve using 15O-water PET without attenuation correction
AU - Tuffier, Stéphane
AU - Legallois, Damien
AU - Belin, Annette
AU - Joubert, Michael
AU - Bailliez, Alban
AU - Redonnet, Michel
AU - Agostini, Denis
AU - Manrique, Alain
N1 - Funding Information:
This work was supported in part by an institutional grant from the Caen University Hospital (AOI 2008-09/089).
Publisher Copyright:
© 2015, Springer-Verlag Berlin Heidelberg.
PY - 2016
Y1 - 2016
N2 - Purpose: Myocardial blood flow (MBF) measurement using positron emission tomography (PET) from the washout rate of 15O-water is theoretically independent of tissue attenuation. The aim of this study was to evaluate the impact of not using attenuation correction in the assessment of coronary endothelial function and myocardial flow reserve (MFR) using 15O-water PET. Methods: We retrospectively processed 70 consecutive 15O-water PET examinations obtained at rest and during cold pressor testing (CPT) in patients with dilated cardiomyopathy (n = 58), or at rest and during adenosine infusion in heart transplant recipients (n = 12). Data were reconstructed with attenuation correction (AC) and without attenuation correction (NAC) using filtered backprojection, and MBF was quantified using a single compartmental model. The agreement between AC and NAC data was assessed using Lin’s concordance correlation coefficient followed by Bland-Altman plot analysis. Results: Regarding endothelial function, NAC PET showed poor reproducibility and poor agreement with AC PET data. Conversely, NAC PET demonstrated high reproducibility and a strong agreement with AC PET for the assessment of MFR. Conclusion: Non-attenuation-corrected 15O-water PET provided an accurate measurement of MFR compared to attenuation-corrected PET. However, non-attenuation-corrected PET data were less effective for the assessment of endothelial function using CPT in this population.
AB - Purpose: Myocardial blood flow (MBF) measurement using positron emission tomography (PET) from the washout rate of 15O-water is theoretically independent of tissue attenuation. The aim of this study was to evaluate the impact of not using attenuation correction in the assessment of coronary endothelial function and myocardial flow reserve (MFR) using 15O-water PET. Methods: We retrospectively processed 70 consecutive 15O-water PET examinations obtained at rest and during cold pressor testing (CPT) in patients with dilated cardiomyopathy (n = 58), or at rest and during adenosine infusion in heart transplant recipients (n = 12). Data were reconstructed with attenuation correction (AC) and without attenuation correction (NAC) using filtered backprojection, and MBF was quantified using a single compartmental model. The agreement between AC and NAC data was assessed using Lin’s concordance correlation coefficient followed by Bland-Altman plot analysis. Results: Regarding endothelial function, NAC PET showed poor reproducibility and poor agreement with AC PET data. Conversely, NAC PET demonstrated high reproducibility and a strong agreement with AC PET for the assessment of MFR. Conclusion: Non-attenuation-corrected 15O-water PET provided an accurate measurement of MFR compared to attenuation-corrected PET. However, non-attenuation-corrected PET data were less effective for the assessment of endothelial function using CPT in this population.
KW - O-water
KW - Attenuation correction
KW - Endothelial function
KW - Myocardial flow reserve
KW - Myocardial perfusion
KW - Positron emission tomography
U2 - 10.1007/s00259-015-3163-x
DO - 10.1007/s00259-015-3163-x
M3 - Journal article
C2 - 26280980
AN - SCOPUS:84952985653
SN - 1619-7070
VL - 43
SP - 288
EP - 295
JO - European Journal of Nuclear Medicine and Molecular Imaging
JF - European Journal of Nuclear Medicine and Molecular Imaging
IS - 2
ER -