TY - JOUR
T1 - Association of alcohol consumption with allergic disease and asthma
T2 - a multi-centre Mendelian randomization analysis
AU - Skaaby, Tea
AU - Kilpeläinen, Tuomas O.
AU - Taylor, Amy E
AU - Mahendran, Yuvaraj
AU - Wong, Andrew
AU - Ahluwalia, Tarunveer S
AU - Paternoster, Lavinia
AU - Trompet, Stella
AU - Stott, David J
AU - Flexeder, Claudia
AU - Zhou, Ang
AU - Brusselle, Guy
AU - Sajjad, Ayesha
AU - Lahousse, Lies
AU - Tiemeier, Henning
AU - Have, Christian Theil
AU - Thuesen, Betina H
AU - Kårhus, Line Lund
AU - Møllehave, Line Tang
AU - Leth-Møller, Katja Biering
AU - Shabanzadeh, Daniel Mønsted
AU - Gonzalez-Quintela, Arturo
AU - Power, Chris
AU - Hyppönen, Elina
AU - Kuh, Diana
AU - Hardy, Rebecca
AU - Meitinger, Thomas
AU - Jukema, J Wouter
AU - Völker, Uwe
AU - Nauck, Matthias
AU - Völzke, Henry
AU - Friedrich, Nele
AU - Bonten, Tobias N
AU - Noordam, Raymond
AU - Mook-Kanamori, Dennis O
AU - Tolstrup, Janne S.
AU - Taube, Christian
AU - Peters, Annette
AU - Grallert, Harald
AU - Strauch, Konstantin
AU - Schulz, Holger
AU - Grarup, Niels
AU - Hansen, Torben
AU - Pedersen, Oluf
AU - Burgess, Stephen
AU - Munafò, Marcus R
AU - Linneberg, Allan
N1 - © 2018 Society for the Study of Addiction.
PY - 2019
Y1 - 2019
N2 - AIMS: To use the rs1229984 variant associated with alcohol consumption as an instrument for alcohol consumption to test the causality of the association of alcohol consumption with hay fever, asthma, allergic sensitization and serum total immunoglobulin (Ig)E.DESIGN: Observational and Mendelian randomization analyses using genetic variants as unbiased markers of exposure to estimate causal effects, subject to certain assumptions.SETTING: Europe.PARTICIPANTS: We included a total of 466 434 people aged 15-82 years from 17 population-based studies conducted from 1997 to 2015.MEASUREMENTS: The rs1229984 (ADH1B) was genotyped; alcohol consumption, hay fever and asthma were self-reported. Specific and total IgE were measured from serum samples.FINDINGS: Observational analyses showed that ever-drinking versus non-drinking, but not amount of alcohol intake, was positively associated with hay fever and inversely associated with asthma but not with allergic sensitization or serum total immunoglobulin (Ig)E. However, Mendelian randomization analyses did not suggest that the observational associations are causal. The causal odds ratio (OR) per genetically assessed unit of alcohol/week was an OR = 0.907 [95% confidence interval (CI) = 0.806, 1.019; P = 0.101] for hay fever, an OR = 0.897 (95% CI = 0.790, 1.019; P = 0.095) for asthma, an OR = 0.971 (95% CI = 0.804, 1.174; P = 0.763) for allergic sensitization and a 4.7% change (95% CI = -5.5%, 14.9%; P = 0.366) for total IgE.CONCLUSIONS: In observational analyses, ever-drinking versus not drinking was positively associated with hay fever and negatively associated with asthma. However, the Mendelian randomization results were not consistent with these associations being causal.
AB - AIMS: To use the rs1229984 variant associated with alcohol consumption as an instrument for alcohol consumption to test the causality of the association of alcohol consumption with hay fever, asthma, allergic sensitization and serum total immunoglobulin (Ig)E.DESIGN: Observational and Mendelian randomization analyses using genetic variants as unbiased markers of exposure to estimate causal effects, subject to certain assumptions.SETTING: Europe.PARTICIPANTS: We included a total of 466 434 people aged 15-82 years from 17 population-based studies conducted from 1997 to 2015.MEASUREMENTS: The rs1229984 (ADH1B) was genotyped; alcohol consumption, hay fever and asthma were self-reported. Specific and total IgE were measured from serum samples.FINDINGS: Observational analyses showed that ever-drinking versus non-drinking, but not amount of alcohol intake, was positively associated with hay fever and inversely associated with asthma but not with allergic sensitization or serum total immunoglobulin (Ig)E. However, Mendelian randomization analyses did not suggest that the observational associations are causal. The causal odds ratio (OR) per genetically assessed unit of alcohol/week was an OR = 0.907 [95% confidence interval (CI) = 0.806, 1.019; P = 0.101] for hay fever, an OR = 0.897 (95% CI = 0.790, 1.019; P = 0.095) for asthma, an OR = 0.971 (95% CI = 0.804, 1.174; P = 0.763) for allergic sensitization and a 4.7% change (95% CI = -5.5%, 14.9%; P = 0.366) for total IgE.CONCLUSIONS: In observational analyses, ever-drinking versus not drinking was positively associated with hay fever and negatively associated with asthma. However, the Mendelian randomization results were not consistent with these associations being causal.
KW - Alcohol
KW - allergic disease
KW - allergic sensitization
KW - asthma
KW - hay fever
KW - mendelian randomization
U2 - 10.1111/add.14438
DO - 10.1111/add.14438
M3 - Journal article
C2 - 30209858
VL - 114
SP - 216
EP - 225
JO - Addiction
JF - Addiction
SN - 0965-2140
IS - 2
ER -