Association of Immunoglobulin G3 Hinge Region Length Polymorphism With Cerebral Malaria in Ghanaian Children

Eric Kyei-Baafour; Kwadwo A. Kusi; Fareed K.N. Arthur; Tracy Sarkodie-Addo; Michael Theisen; Daniel Dodoo; Bright Adu

doi:10.1093/infdis/jiab548

Association of Immunoglobulin G3 Hinge Region Length Polymorphism With Cerebral Malaria in Ghanaian Children

Eric Kyei-Baafour, Kwadwo A. Kusi, Fareed K.N. Arthur, Tracy Sarkodie-Addo, Michael Theisen, Daniel Dodoo, Bright Adu

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

1 Citationer (Scopus)

Abstract

Cerebral malaria (CM) may cause death or long-term neurological damage in children, and several host genetic risk factors have been reported. Malaria-specific immunoglobulin (Ig) G3 antibodies are crucial to human immune response against malaria. The hinge region of IgG3 exhibits length polymorphism (with long [L], medium [M], and short [S] alleles), which may influence its functionality. We studied IgG3 hinge region length polymorphisms in 136 Ghanaian children with malaria. Using logistic regression models, we found that children with the recessive MM allotype encoding medium IgG3 hinge region length had an increased risk of CM (adjusted odds ratio, 6.67 [95% confidence interval,1.30-34.32]; P=.004) . This has implications for future epidemiological studies on CM.

Originalsprog	Engelsk
Tidsskrift	The Journal of Infectious Diseases
Vol/bind	225
Udgave nummer	10
Sider (fra-til)	1786-1790
Antal sider	5
ISSN	0022-1899
DOI	https://doi.org/10.1093/infdis/jiab548
Status	Udgivet - 2022

Bibliografisk note

Publisher Copyright:
© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].

Adgang til dokumentet

10.1093/infdis/jiab548

Citationsformater

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title = "Association of Immunoglobulin G3 Hinge Region Length Polymorphism With Cerebral Malaria in Ghanaian Children",

abstract = "Cerebral malaria (CM) may cause death or long-term neurological damage in children, and several host genetic risk factors have been reported. Malaria-specific immunoglobulin (Ig) G3 antibodies are crucial to human immune response against malaria. The hinge region of IgG3 exhibits length polymorphism (with long [L], medium [M], and short [S] alleles), which may influence its functionality. We studied IgG3 hinge region length polymorphisms in 136 Ghanaian children with malaria. Using logistic regression models, we found that children with the recessive MM allotype encoding medium IgG3 hinge region length had an increased risk of CM (adjusted odds ratio, 6.67 [95% confidence interval,1.30-34.32]; P=.004) . This has implications for future epidemiological studies on CM.",

keywords = "IGHG3 gene, cerebral malaria, IgG3 hinge region, Plasmodium falciparum, polymorphism",

author = "Eric Kyei-Baafour and Kusi, {Kwadwo A.} and Arthur, {Fareed K.N.} and Tracy Sarkodie-Addo and Michael Theisen and Daniel Dodoo and Bright Adu",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].",

year = "2022",

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T1 - Association of Immunoglobulin G3 Hinge Region Length Polymorphism With Cerebral Malaria in Ghanaian Children

AU - Kyei-Baafour, Eric

AU - Kusi, Kwadwo A.

AU - Arthur, Fareed K.N.

AU - Sarkodie-Addo, Tracy

AU - Theisen, Michael

AU - Dodoo, Daniel

AU - Adu, Bright

PY - 2022

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N2 - Cerebral malaria (CM) may cause death or long-term neurological damage in children, and several host genetic risk factors have been reported. Malaria-specific immunoglobulin (Ig) G3 antibodies are crucial to human immune response against malaria. The hinge region of IgG3 exhibits length polymorphism (with long [L], medium [M], and short [S] alleles), which may influence its functionality. We studied IgG3 hinge region length polymorphisms in 136 Ghanaian children with malaria. Using logistic regression models, we found that children with the recessive MM allotype encoding medium IgG3 hinge region length had an increased risk of CM (adjusted odds ratio, 6.67 [95% confidence interval,1.30-34.32]; P=.004) . This has implications for future epidemiological studies on CM.

AB - Cerebral malaria (CM) may cause death or long-term neurological damage in children, and several host genetic risk factors have been reported. Malaria-specific immunoglobulin (Ig) G3 antibodies are crucial to human immune response against malaria. The hinge region of IgG3 exhibits length polymorphism (with long [L], medium [M], and short [S] alleles), which may influence its functionality. We studied IgG3 hinge region length polymorphisms in 136 Ghanaian children with malaria. Using logistic regression models, we found that children with the recessive MM allotype encoding medium IgG3 hinge region length had an increased risk of CM (adjusted odds ratio, 6.67 [95% confidence interval,1.30-34.32]; P=.004) . This has implications for future epidemiological studies on CM.

KW - IGHG3 gene

KW - cerebral malaria

KW - IgG3 hinge region

KW - Plasmodium falciparum

KW - polymorphism

U2 - 10.1093/infdis/jiab548

DO - 10.1093/infdis/jiab548

M3 - Journal article

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AN - SCOPUS:85130765425

SN - 0022-1899

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JO - The Journal of Infectious Diseases

JF - The Journal of Infectious Diseases

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