Association of interferon-gamma and interleukin 10 genotypes and serum levels with partial clinical remission in type 1 diabetes

B Z Alizadeh, P Hanifi-Moghaddam, P Eerligh, A R van der Slik, H Kolb, A V Kharagjitsingh, A M Pereira Arias, M Ronkainen, M Knip, R Bonfanti, E Bonifacio, Devendra Prasad, T Wilkin, M J Giphart, B P C Koeleman, R Nolsøe, Thomas Mandrup-Poulsen, N C Schloot, B O Roep, DIABMARKER Study Group

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Abstract

We studied whether serum interferon (IFN)-gamma or interleukin (IL)-10 levels and their corresponding functional polymorphic genotypes are associated with partial remission of type 1 diabetes (T1D). A multi-centre study was undertaken in patients with newly diagnosed T1D and matched controls. T1D patients were followed for 3 months and characterized for remission status. Partial clinical remission was defined as a daily insulin dose
OriginalsprogEngelsk
TidsskriftClinical and Experimental Immunology
Vol/bind145
Udgave nummer3
Sider (fra-til)480-4
Antal sider5
ISSN0009-9104
DOI
StatusUdgivet - 1 sep. 2006

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