Astrocytes: integrators of arousal state and sensory context

Rune Nguyen Rasmussen; Antonis Asiminas; Eva Maria Meier Carlsen; Celia Kjaerby; Nathan Anthony Smith

doi:10.1016/j.tins.2023.03.003

Astrocytes: integrators of arousal state and sensory context

Rune Nguyen Rasmussen^*, Antonis Asiminas, Eva Maria Meier Carlsen, Celia Kjaerby, Nathan Anthony Smith

^*Corresponding author af dette arbejde

Center for Translational Neuromedicine

Publikation: Bidrag til tidsskrift › Review › Forskning › peer review

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Abstract

The integration of external information with the internal state of the body is central to the survival of virtually every multicellular organism. However, a complete picture of the mechanisms that govern this process is lacking. In this opinion article, we synthesize evidence demonstrating that astrocytes sense the momentary arousal state – through neuromodulator release – as well as the sensory inputs – through local synaptic activity – and respond to them with changes in calcium (Ca²⁺) signaling. We hypothesize that astrocytes integrate sensory signals with the internal state and that this process is necessary to secure optimal behavior. Finally, we argue that dysfunctional astrocytic Ca²⁺ signaling could be an underlying factor in disorders characterized by disrupted sensory processing.

Originalsprog	Engelsk
Tidsskrift	Trends in Neurosciences
Vol/bind	46
Udgave nummer	6
Antal sider	8
ISSN	0166-2236
DOI	https://doi.org/10.1016/j.tins.2023.03.003
Status	Udgivet - 2023

Bibliografisk note

Funding Information:
We thank members of the Center for Translational Neuromedicine and the Del Monte Institute for Neuroscience for discussions on the ideas presented in this opinion article. This work was supported by National Institutes of Health Grant K01NS110981 to N.A.S. National Science Foundation NSF1926781 to N.A.S. the EU under a Marie Skłodowska-Curie Fellowship (ANCoDy, #101064009) to A.A. an ONO Rising Star Fellowship to A.A. a Lundbeck Foundation, Experiment Grant to R.N.R. (R370-2021-764), and the Novo Nordisk Foundation (NNF20OC0066419) to C.K. The authors declare no interests.

Funding Information:
We thank members of the Center for Translational Neuromedicine and the Del Monte Institute for Neuroscience for discussions on the ideas presented in this opinion article. This work was supported by National Institutes of Health Grant K01NS110981 to N.A.S., National Science Foundation NSF1926781 to N.A.S., the EU under a Marie Skłodowska-Curie Fellowship (ANCoDy, # 101064009 ) to A.A., an ONO Rising Star Fellowship to A.A., a Lundbeck Foundation , Experiment Grant to R.N.R. ( R370-2021-764 ), and the Novo Nordisk Foundation ( NNF20OC0066419 ) to C.K.

Publisher Copyright:
© 2023 The Authors

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Citationsformater

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abstract = "The integration of external information with the internal state of the body is central to the survival of virtually every multicellular organism. However, a complete picture of the mechanisms that govern this process is lacking. In this opinion article, we synthesize evidence demonstrating that astrocytes sense the momentary arousal state – through neuromodulator release – as well as the sensory inputs – through local synaptic activity – and respond to them with changes in calcium (Ca2+) signaling. We hypothesize that astrocytes integrate sensory signals with the internal state and that this process is necessary to secure optimal behavior. Finally, we argue that dysfunctional astrocytic Ca2+ signaling could be an underlying factor in disorders characterized by disrupted sensory processing.",

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T2 - integrators of arousal state and sensory context

AU - Rasmussen, Rune Nguyen

AU - Asiminas, Antonis

AU - Carlsen, Eva Maria Meier

AU - Kjaerby, Celia

AU - Smith, Nathan Anthony

PY - 2023

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AB - The integration of external information with the internal state of the body is central to the survival of virtually every multicellular organism. However, a complete picture of the mechanisms that govern this process is lacking. In this opinion article, we synthesize evidence demonstrating that astrocytes sense the momentary arousal state – through neuromodulator release – as well as the sensory inputs – through local synaptic activity – and respond to them with changes in calcium (Ca2+) signaling. We hypothesize that astrocytes integrate sensory signals with the internal state and that this process is necessary to secure optimal behavior. Finally, we argue that dysfunctional astrocytic Ca2+ signaling could be an underlying factor in disorders characterized by disrupted sensory processing.

KW - calcium signaling

KW - glial cells

KW - internal state

KW - neuromodulation

KW - sensory processing

U2 - 10.1016/j.tins.2023.03.003

DO - 10.1016/j.tins.2023.03.003

M3 - Review

C2 - 37003933

AN - SCOPUS:85151355816

VL - 46

JO - Trends in Neurosciences

JF - Trends in Neurosciences

SN - 0378-5912

IS - 6

ER -