Atom-by-atom engineering of voltage-gated ion channels: Magnified insights into function and pharmacology

Stephan Alexander Pless, Robin Y Kim, Christopher A Ahern, Harley T Kurata

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

7 Citationer (Scopus)

Abstract

Unnatural amino acid incorporation into ion channels has proven to be a valuable approach to interrogate detailed hypotheses arising from atomic resolution structures. In this short review, we provide a brief overview of some of the basic principles and methods for incorporation of unnatural amino acids into proteins. We also review insights into the function and pharmacology of voltage-gated ion channels that have emerged from unnatural amino acid mutagenesis approaches.

OriginalsprogEngelsk
TidsskriftThe Journal of Physiology
Vol/bind593
Udgave nummer12
Sider (fra-til)2627–2634
Antal sider8
ISSN0022-3751
DOI
StatusUdgivet - 30 jan. 2015

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