Abstract
Unnatural amino acid incorporation into ion channels has proven to be a valuable approach to interrogate detailed hypotheses arising from atomic resolution structures. In this short review, we provide a brief overview of some of the basic principles and methods for incorporation of unnatural amino acids into proteins. We also review insights into the function and pharmacology of voltage-gated ion channels that have emerged from unnatural amino acid mutagenesis approaches.
Originalsprog | Engelsk |
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Tidsskrift | The Journal of Physiology |
Vol/bind | 593 |
Udgave nummer | 12 |
Sider (fra-til) | 2627–2634 |
Antal sider | 8 |
ISSN | 0022-3751 |
DOI | |
Status | Udgivet - 30 jan. 2015 |