Autoantibodies to MUC1 glycopeptides cannot be used as a screening assay for early detection of breast, ovarian, lung or pancreatic cancer

B Burford; A Gentry-Maharaj; R Graham; D Allen; J W Pedersen; A S Nudelman; Klas Ola Blixt; E O Fourkala; D Bueti; A Dawnay; J Ford; R Desai; L David; P Trinder; B Acres; T Schwientek; A Gammerman; C A Reis; Lara Patricia Marcos da Silva; H Osório; R Hallett; H H Wandall; U Mandel; M A Hollingsworth; I Jacobs; I Fentiman; H Clausen; J Taylor-Papadimitriou; U Menon; J M Burchell

doi:10.1038/bjc.2013.214

Autoantibodies to MUC1 glycopeptides cannot be used as a screening assay for early detection of breast, ovarian, lung or pancreatic cancer

B Burford, A Gentry-Maharaj, R Graham, D Allen, J W Pedersen, A S Nudelman, Klas Ola Blixt, E O Fourkala, D Bueti, A Dawnay, J Ford, R Desai, L David, P Trinder, B Acres, T Schwientek, A Gammerman, C A Reis, Lara Patricia Marcos da Silva, H OsórioR Hallett, H H Wandall, U Mandel, M A Hollingsworth, I Jacobs, I Fentiman, H Clausen, J Taylor-Papadimitriou, U Menon, J M Burchell

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

51 Citationer (Scopus)

Abstract

Autoantibodies have been detected in sera before diagnosis of cancer leading to interest in their potential as screening/early detection biomarkers. As we have found autoantibodies to MUC1 glycopeptides to be elevated in early-stage breast cancer patients, in this study we analysed these autoantibodies in large population cohorts of sera taken before cancer diagnosis.

Originalsprog	Engelsk
Tidsskrift	B J C
Vol/bind	108
Udgave nummer	10
Sider (fra-til)	2045-55
Antal sider	11
ISSN	0007-0920
DOI	https://doi.org/10.1038/bjc.2013.214
Status	Udgivet - 28 maj 2013

Adgang til dokumentet

10.1038/bjc.2013.214

Citationsformater

Burford, B., Gentry-Maharaj, A., Graham, R., Allen, D., Pedersen, J. W., Nudelman, A. S., Blixt, K. O., Fourkala, E. O., Bueti, D., Dawnay, A., Ford, J., Desai, R., David, L., Trinder, P., Acres, B., Schwientek, T., Gammerman, A., Reis, C. A., da Silva, L. P. M., ... Burchell, J. M. (2013). Autoantibodies to MUC1 glycopeptides cannot be used as a screening assay for early detection of breast, ovarian, lung or pancreatic cancer. B J C, 108(10), 2045-55. https://doi.org/10.1038/bjc.2013.214

Burford, B, Gentry-Maharaj, A, Graham, R, Allen, D, Pedersen, JW, Nudelman, AS, Blixt, KO, Fourkala, EO, Bueti, D, Dawnay, A, Ford, J, Desai, R, David, L, Trinder, P, Acres, B, Schwientek, T, Gammerman, A, Reis, CA, da Silva, LPM, Osório, H, Hallett, R, Wandall, HH , Mandel, U, Hollingsworth, MA, Jacobs, I, Fentiman, I, Clausen, H, Taylor-Papadimitriou, J, Menon, U & Burchell, JM 2013, 'Autoantibodies to MUC1 glycopeptides cannot be used as a screening assay for early detection of breast, ovarian, lung or pancreatic cancer', B J C, bind 108, nr. 10, s. 2045-55. https://doi.org/10.1038/bjc.2013.214

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abstract = "Autoantibodies have been detected in sera before diagnosis of cancer leading to interest in their potential as screening/early detection biomarkers. As we have found autoantibodies to MUC1 glycopeptides to be elevated in early-stage breast cancer patients, in this study we analysed these autoantibodies in large population cohorts of sera taken before cancer diagnosis.",

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T1 - Autoantibodies to MUC1 glycopeptides cannot be used as a screening assay for early detection of breast, ovarian, lung or pancreatic cancer

AU - Burford, B

AU - Gentry-Maharaj, A

AU - Graham, R

AU - Allen, D

AU - Pedersen, J W

AU - Nudelman, A S

AU - Blixt, Klas Ola

AU - Fourkala, E O

AU - Bueti, D

AU - Dawnay, A

AU - Ford, J

AU - Desai, R

AU - David, L

AU - Trinder, P

AU - Acres, B

AU - Schwientek, T

AU - Gammerman, A

AU - Reis, C A

AU - da Silva, Lara Patricia Marcos

AU - Osório, H

AU - Hallett, R

AU - Wandall, H H

AU - Mandel, U

AU - Hollingsworth, M A

AU - Jacobs, I

AU - Fentiman, I

AU - Clausen, H

AU - Taylor-Papadimitriou, J

AU - Menon, U

AU - Burchell, J M

PY - 2013/5/28

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AB - Autoantibodies have been detected in sera before diagnosis of cancer leading to interest in their potential as screening/early detection biomarkers. As we have found autoantibodies to MUC1 glycopeptides to be elevated in early-stage breast cancer patients, in this study we analysed these autoantibodies in large population cohorts of sera taken before cancer diagnosis.

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DO - 10.1038/bjc.2013.214

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