Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Scandinavian Journal of Infectious Diseases |
| Vol/bind | 38 |
| Udgave nummer | 11-12 |
| Sider (fra-til) | 1063-8 |
| Antal sider | 5 |
| ISSN | 0036-5548 |
| DOI | |
| Status | Udgivet - 2006 |
Bibliografisk note
Keywords: Animals; Biological Markers; Chromatography; Clinical Competence; Diagnostic Errors; Humans; Malaria; Plasmodium; Platelet Count; Point-of-Care Systems; Predictive Value of Tests; Reagent Kits, DiagnosticAdgang til dokumentet
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I: Scandinavian Journal of Infectious Diseases, Bind 38, Nr. 11-12, 2006, s. 1063-8.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
}
TY - JOUR
T1 - Bedside diagnosis of imported malaria using the Binax Now malaria antigen detection test
AU - Wiese, Lothar
AU - Bruun, Brita
AU - Baek, Leif
AU - Friis-Møller, Alice
AU - Gahrn-Hansen, Bente
AU - Hansen, Joanna
AU - Heltberg, Ole
AU - Højbjerg, Tove
AU - Hornstrup, Maren Kathrine
AU - Kvinesdal, Birgit
AU - Gomme, Grethe
AU - Kurtzhals, Jørgen
N1 - Keywords: Animals; Biological Markers; Chromatography; Clinical Competence; Diagnostic Errors; Humans; Malaria; Plasmodium; Platelet Count; Point-of-Care Systems; Predictive Value of Tests; Reagent Kits, Diagnostic
PY - 2006
Y1 - 2006
N2 - Malaria may be misdiagnosed in non-endemic countries when the necessary experience for rapid expert microscopy is lacking. Rapid diagnostic tests may improve the diagnosis and may play a role as a bedside diagnostic tool. In a multicentre study we recruited patients suspected of malaria over a period of 14 months. The Binax Now Malaria rapid test was used at the bedside and in the clinical microbiology laboratory. The training of clinical staff was monitored and their experience with the use of the test was recorded. 542 patients were included, 80 of whom had malaria diagnosed by microscopy. The rapid test used at the bedside had a sensitivity of 88% for the detection of P. falciparum compared to 95% when the test was performed in the microbiology laboratory. The risk of technical problems and invalid tests was highest when the test was used at the bedside. The rapid diagnostic test may be useful for the diagnosis of P. falciparum malaria when used by routine laboratory staff, but could lead to misdiagnoses when used at the bedside. Microscopy is still essential in order to identify the few missed diagnoses, to determine the degree of parasitaemia, and to ensure species diagnosis, including mixed infections.
AB - Malaria may be misdiagnosed in non-endemic countries when the necessary experience for rapid expert microscopy is lacking. Rapid diagnostic tests may improve the diagnosis and may play a role as a bedside diagnostic tool. In a multicentre study we recruited patients suspected of malaria over a period of 14 months. The Binax Now Malaria rapid test was used at the bedside and in the clinical microbiology laboratory. The training of clinical staff was monitored and their experience with the use of the test was recorded. 542 patients were included, 80 of whom had malaria diagnosed by microscopy. The rapid test used at the bedside had a sensitivity of 88% for the detection of P. falciparum compared to 95% when the test was performed in the microbiology laboratory. The risk of technical problems and invalid tests was highest when the test was used at the bedside. The rapid diagnostic test may be useful for the diagnosis of P. falciparum malaria when used by routine laboratory staff, but could lead to misdiagnoses when used at the bedside. Microscopy is still essential in order to identify the few missed diagnoses, to determine the degree of parasitaemia, and to ensure species diagnosis, including mixed infections.
U2 - 10.1080/00365540600818011
DO - 10.1080/00365540600818011
M3 - Journal article
C2 - 17148078
SN - 0036-5548
VL - 38
SP - 1063
EP - 1068
JO - Scandinavian Journal of Infectious Diseases
JF - Scandinavian Journal of Infectious Diseases
IS - 11-12
ER -