Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics

Mie Fabricius Pedersen; Tomasz Marcin Wrobel; Emil Märcher-Rørsted; Daniel Sejer Pedersen; Thor Christian Møller; Federica Gabriele; Henrik Pedersen; Dariusz Matosiuk; Simon Richard Foster; Michel Bouvier; Hans Bräuner-Osborne

doi:10.1016/j.neuropharm.2019.107718

Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics

Mie Fabricius Pedersen, Tomasz Marcin Wrobel, Emil Märcher-Rørsted, Daniel Sejer Pedersen, Thor Christian Møller, Federica Gabriele, Henrik Pedersen, Dariusz Matosiuk, Simon Richard Foster, Michel Bouvier, Hans Bräuner-Osborne

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

56 Citationer (Scopus)

197 Downloads (Pure)

Originalsprog	Engelsk
Artikelnummer	107718
Tidsskrift	Neuropharmacology
Vol/bind	166
Antal sider	13
ISSN	0028-3908
DOI	https://doi.org/10.1016/j.neuropharm.2019.107718
Status	Udgivet - 2020

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10.1016/j.neuropharm.2019.107718Licens: CC BY

FulltextForlagets udgivne version, 2,6 MBLicens: CC BY

Citationsformater

Pedersen, M. F., Wrobel, T. M., Märcher-Rørsted, E., Pedersen, D. S., Møller, T. C., Gabriele, F., Pedersen, H., Matosiuk, D., Foster, S. R., Bouvier, M., & Bräuner-Osborne, H. (2020). Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics. Neuropharmacology, 166, [107718]. https://doi.org/10.1016/j.neuropharm.2019.107718

Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics. / Pedersen, Mie Fabricius; Wrobel, Tomasz Marcin; Märcher-Rørsted, Emil; Pedersen, Daniel Sejer; Møller, Thor Christian; Gabriele, Federica; Pedersen, Henrik; Matosiuk, Dariusz; Foster, Simon Richard; Bouvier, Michel; Bräuner-Osborne, Hans.

I: Neuropharmacology, Bind 166, 107718, 2020.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Pedersen, MF, Wrobel, TM, Märcher-Rørsted, E, Pedersen, DS, Møller, TC, Gabriele, F, Pedersen, H, Matosiuk, D, Foster, SR, Bouvier, M & Bräuner-Osborne, H 2020, 'Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics', Neuropharmacology, bind 166, 107718. https://doi.org/10.1016/j.neuropharm.2019.107718

Pedersen, Mie Fabricius ; Wrobel, Tomasz Marcin ; Märcher-Rørsted, Emil ; Pedersen, Daniel Sejer ; Møller, Thor Christian ; Gabriele, Federica ; Pedersen, Henrik ; Matosiuk, Dariusz ; Foster, Simon Richard ; Bouvier, Michel ; Bräuner-Osborne, Hans. / Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics. I: Neuropharmacology. 2020 ; Bind 166.

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title = "Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics",

keywords = "Biased agonism, Binding kinetics, mu-opioid receptor, Oliceridine ((R)-TRV130)",

author = "Pedersen, {Mie Fabricius} and Wrobel, {Tomasz Marcin} and Emil M{\"a}rcher-R{\o}rsted and Pedersen, {Daniel Sejer} and M{\o}ller, {Thor Christian} and Federica Gabriele and Henrik Pedersen and Dariusz Matosiuk and Foster, {Simon Richard} and Michel Bouvier and Hans Br{\"a}uner-Osborne",

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T1 - Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics

AU - Pedersen, Mie Fabricius

AU - Wrobel, Tomasz Marcin

AU - Märcher-Rørsted, Emil

AU - Pedersen, Daniel Sejer

AU - Møller, Thor Christian

AU - Gabriele, Federica

AU - Pedersen, Henrik

AU - Matosiuk, Dariusz

AU - Foster, Simon Richard

AU - Bouvier, Michel

AU - Bräuner-Osborne, Hans

PY - 2020

Y1 - 2020

KW - Biased agonism

KW - Binding kinetics

KW - mu-opioid receptor

KW - Oliceridine ((R)-TRV130)

U2 - 10.1016/j.neuropharm.2019.107718

DO - 10.1016/j.neuropharm.2019.107718

M3 - Journal article

C2 - 31351108

VL - 166

JO - Neuropharmacology

JF - Neuropharmacology

SN - 0028-3908

M1 - 107718

ER -