Bioassay-guided isolation of apigenin with GABA-benzodiazepine activity from Tanacetum parthenium

Anna Katharina Jäger; Katrine Krydsfeldt; Hasse Bonde Rasmussen

doi:10.1002/ptr.2816

Bioassay-guided isolation of apigenin with GABA-benzodiazepine activity from Tanacetum parthenium

Anna Katharina Jäger, Katrine Krydsfeldt, Hasse Bonde Rasmussen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

44 Citationer (Scopus)

Abstract

Extracts of Tanacetum parthenium are used in the prophylactic treatment of migraine and have also been used in Danish folk medicine for the treatment of epilepsy. An ethanol extract of T. parthenium showed high affinity for the GABA(A)-benzodiazepine site. An ethanol extract of T. parthenium was fractionated by VLC on silica and preparative C18 HPLC. Each step was monitored with the GABA(A)-benzodiazepine bioassay. The fractionation led to the isolation of apigenin, which may be responsible for CNS-effects of T. parthenium extracts. Copyright (c) 2009 John Wiley & Sons, Ltd.

Originalsprog	Engelsk
Tidsskrift	Phytotherapy Research
Vol/bind	23
Udgave nummer	11
Sider (fra-til)	1642-1644
ISSN	0951-418X
DOI	https://doi.org/10.1002/ptr.2816
Status	Udgivet - 2009

Bibliografisk note

Keywords: apigenin; benzodiazepine site; GABA; Tanacetum parthenium

Emneord

Det tidligere Farmaceutiske Fakultet

Adgang til dokumentet

10.1002/ptr.2816

Citationsformater

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abstract = "Extracts of Tanacetum parthenium are used in the prophylactic treatment of migraine and have also been used in Danish folk medicine for the treatment of epilepsy. An ethanol extract of T. parthenium showed high affinity for the GABA(A)-benzodiazepine site. An ethanol extract of T. parthenium was fractionated by VLC on silica and preparative C18 HPLC. Each step was monitored with the GABA(A)-benzodiazepine bioassay. The fractionation led to the isolation of apigenin, which may be responsible for CNS-effects of T. parthenium extracts. Copyright (c) 2009 John Wiley & Sons, Ltd.",

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AU - Rasmussen, Hasse Bonde

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AB - Extracts of Tanacetum parthenium are used in the prophylactic treatment of migraine and have also been used in Danish folk medicine for the treatment of epilepsy. An ethanol extract of T. parthenium showed high affinity for the GABA(A)-benzodiazepine site. An ethanol extract of T. parthenium was fractionated by VLC on silica and preparative C18 HPLC. Each step was monitored with the GABA(A)-benzodiazepine bioassay. The fractionation led to the isolation of apigenin, which may be responsible for CNS-effects of T. parthenium extracts. Copyright (c) 2009 John Wiley & Sons, Ltd.

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