Abstract
Objective:
Although preterm-born and low-birth-weight individuals have an increased risk of cardiovascular diseases in adulthood, little is known regarding early cardiovascular and renal damage (CVRD) or hypertension in adulthood. Our study investigated the association of birth weight with early CVRD markers as well as the heritability of birth weight in an initially healthy family-based cohort.
Methods:
This study was based on 1028 individuals from the familial longitudinal STANISLAS cohort (399 parents/629 children) initiated in 1993–1995, with a fourth examination conducted in 2011–2016. Analyses performed at the fourth visit included pulse-wave velocity, central pressure, ambulatory blood pressure, hypertension status, diastolic dysfunction/distensibility, left ventricular mass indexed (LVMI), carotid intima–media thickness and kidney damage. The family structure of the cohort allowed birth weight heritability estimation.
Results:
Mean (±SD) birth weight was 3.3 ± 0.6 kg. Heritability was moderate (42–44%). At the fourth visit, individuals were 37 years old (32.0–57.0), 56% were women and 13% had antihypertensive treatment. Birth weight was strongly and negatively associated with hypertension [odds ratio (OR) 95% confidence interval (CI) 0.61 (0.45–0.84)]. A nonlinear association was found with LVMI, participants with a birth weight greater than 3 kg having a higher LVMI. A positive association (β 95% CI 5.09 (1.8–8.38)] was also observed between birth weight and distensibility for adults with normal BMI. No associations were found with other CVRD.
Conclusion:
In this middle-aged population, birth weight was strongly and negatively associated with hypertension, and positively associated with distensibility in adults with normal BMI and with LVMI for higher birth weights. No associations were found with other CVRD markers.
Although preterm-born and low-birth-weight individuals have an increased risk of cardiovascular diseases in adulthood, little is known regarding early cardiovascular and renal damage (CVRD) or hypertension in adulthood. Our study investigated the association of birth weight with early CVRD markers as well as the heritability of birth weight in an initially healthy family-based cohort.
Methods:
This study was based on 1028 individuals from the familial longitudinal STANISLAS cohort (399 parents/629 children) initiated in 1993–1995, with a fourth examination conducted in 2011–2016. Analyses performed at the fourth visit included pulse-wave velocity, central pressure, ambulatory blood pressure, hypertension status, diastolic dysfunction/distensibility, left ventricular mass indexed (LVMI), carotid intima–media thickness and kidney damage. The family structure of the cohort allowed birth weight heritability estimation.
Results:
Mean (±SD) birth weight was 3.3 ± 0.6 kg. Heritability was moderate (42–44%). At the fourth visit, individuals were 37 years old (32.0–57.0), 56% were women and 13% had antihypertensive treatment. Birth weight was strongly and negatively associated with hypertension [odds ratio (OR) 95% confidence interval (CI) 0.61 (0.45–0.84)]. A nonlinear association was found with LVMI, participants with a birth weight greater than 3 kg having a higher LVMI. A positive association (β 95% CI 5.09 (1.8–8.38)] was also observed between birth weight and distensibility for adults with normal BMI. No associations were found with other CVRD.
Conclusion:
In this middle-aged population, birth weight was strongly and negatively associated with hypertension, and positively associated with distensibility in adults with normal BMI and with LVMI for higher birth weights. No associations were found with other CVRD markers.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Journal of Hypertension |
| Vol/bind | 41 |
| Udgave nummer | 6 |
| Sider (fra-til) | 1040-1050 |
| Antal sider | 11 |
| ISSN | 0263-6352 |
| DOI | |
| Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:Funding sources: The STANISLAS study is sponsored by Nancy CHRU. This work is supported by the French Ministry of Health ‘Programme Hospitalier de Recherche Clinique Inter regional 2013’, by the Contrat de Plan Etat- Lorraine and FEDER Lorraine, and a public grant overseen by the French National Research Agency (ANR) as part of the second ‘Investissements d’Avenir’ program FIGHT-HF (reference: ANR-15-RHU-0004) and by the French PIA project ‘Lorraine Université d’Excellence’, reference ANR-15-IDEX-04-LUE. It is also supported by the European Fibro-Targets Project (grant agreement No. SP7#602904), European HOMAGE project (Heart ‘Omics’ in Ageing, 7th Framework Program grant # 305507), the MEDIA project (Européen ‘Cooperation’ – Theme ‘Health’/FP7-HEALTH-2010-single-stage (reference: 261409), FOCUS-MR (reference: ANR-15-CE14-0032-01), ERA-CVD EXPERT (reference: ANR-16-ECVD-0002-02) and the Fondation de Recherche en Hypertension Artérielle).
Funding Information:
The studies mentioned were sponsored by the Nancy CHRU. They were supported by the Programme Hospitalier de Recherche Clinique (PHRC), by a public grant overseen by the French National Research Agency (ANR) as part of the second ‘Investissements d’Avenir’ programme (reference: ANR-15-RHU-0004), and Contrat de Plan Etat Région Lorraine and FEDER, La Région Lorraine, and la Fondation de Recherche en Hypertension artérielle, and by the EU FP6 program Ingenius Hypercare.
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