Bisphosphonate kinetics in patients undergoing continuous ambulatory peritoneal dialysis: relations to dynamic bone histomorphometry, osteocalcin and parathyroid hormone

P Joffe; L Hyldstrup; J G Heaf; J Pødenphant; Jens Henrik Sahl Henriksen

Bisphosphonate kinetics in patients undergoing continuous ambulatory peritoneal dialysis: relations to dynamic bone histomorphometry, osteocalcin and parathyroid hormone

P Joffe, L Hyldstrup, J G Heaf, J Pødenphant, Jens Henrik Sahl Henriksen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

9 Citationer (Scopus)

Abstract

Udgivelsesdato: 1992-null

Originalsprog	Engelsk
Tidsskrift	American Journal of Nephrology
Vol/bind	12
Udgave nummer	6
Sider (fra-til)	419-24
Antal sider	5
ISSN	0250-8095
Status	Udgivet - 1992

Bibliografisk note

Keywords: Adult; Aged; Aged, 80 and over; Alkaline Phosphatase; Biopsy; Bone Resorption; Bone and Bones; Calcium; Diphosphonates; Female; Humans; Male; Middle Aged; Osteocalcin; Parathyroid Hormone; Peritoneal Dialysis, Continuous Ambulatory; Phosphates; Renal Osteodystrophy

Citationsformater

@article{e4b85470326711df8ed1000ea68e967b,

title = "Bisphosphonate kinetics in patients undergoing continuous ambulatory peritoneal dialysis: relations to dynamic bone histomorphometry, osteocalcin and parathyroid hormone",

abstract = "In the evaluation of renal osteodystrophy bone biopsy is often performed. However, a reliable noninvasive test could be very useful, and recently the estimation of osseous tracer uptake as an index of bone formation has been introduced-the bone bisphosphonate clearance (BBC). The aim of the present investigation therefore was to compare BBC with parameters of bone histology, serum levels of osteocalcin, alkaline phosphatase, and parathyroid hormone in patients (n = 8) undergoing continuous ambulatory peritoneal dialysis (CAPD). No significant correlations were found between BBC values and the bone histomorphometrical variables measured. A positive correlation was seen between serum osteocalcin and resorption and active resorption surface (p < 0.05), as well as tetracycline-labelled surface, bone formation rate, surfaces, volume and tissue referents, respectively (p < 0.01). Furthermore, levels of alkaline phosphatase showed significant correlations to mineral appositional rate, tetracycline-labelled surface and bone formation rate, volume referent (p < 0.05). Values of parathyroid hormone were significantly correlated to resorption surface (p < 0.02), active resorption surface, mineral appositional rate and mineralization lag time (p < 0.05). In conclusion, BBC was of no use in patients treated with CAPD as a noninvasive test for evaluation of bone histomorphometry. However, osteocalcin correlated best with resorption and bone dynamics indices. Levels of alkaline phosphatase and parathyroid hormone were of a more limited value.",

author = "P Joffe and L Hyldstrup and Heaf, {J G} and J P{\o}denphant and Henriksen, {Jens Henrik Sahl}",

note = "Keywords: Adult; Aged; Aged, 80 and over; Alkaline Phosphatase; Biopsy; Bone Resorption; Bone and Bones; Calcium; Diphosphonates; Female; Humans; Male; Middle Aged; Osteocalcin; Parathyroid Hormone; Peritoneal Dialysis, Continuous Ambulatory; Phosphates; Renal Osteodystrophy",

year = "1992",

language = "English",

volume = "12",

pages = "419--24",

journal = "American Journal of Nephrology",

issn = "0250-8095",

publisher = "S Karger AG",

number = "6",

}

TY - JOUR

T1 - Bisphosphonate kinetics in patients undergoing continuous ambulatory peritoneal dialysis: relations to dynamic bone histomorphometry, osteocalcin and parathyroid hormone

AU - Joffe, P

AU - Hyldstrup, L

AU - Heaf, J G

AU - Pødenphant, J

AU - Henriksen, Jens Henrik Sahl

N1 - Keywords: Adult; Aged; Aged, 80 and over; Alkaline Phosphatase; Biopsy; Bone Resorption; Bone and Bones; Calcium; Diphosphonates; Female; Humans; Male; Middle Aged; Osteocalcin; Parathyroid Hormone; Peritoneal Dialysis, Continuous Ambulatory; Phosphates; Renal Osteodystrophy

PY - 1992

Y1 - 1992

N2 - In the evaluation of renal osteodystrophy bone biopsy is often performed. However, a reliable noninvasive test could be very useful, and recently the estimation of osseous tracer uptake as an index of bone formation has been introduced-the bone bisphosphonate clearance (BBC). The aim of the present investigation therefore was to compare BBC with parameters of bone histology, serum levels of osteocalcin, alkaline phosphatase, and parathyroid hormone in patients (n = 8) undergoing continuous ambulatory peritoneal dialysis (CAPD). No significant correlations were found between BBC values and the bone histomorphometrical variables measured. A positive correlation was seen between serum osteocalcin and resorption and active resorption surface (p < 0.05), as well as tetracycline-labelled surface, bone formation rate, surfaces, volume and tissue referents, respectively (p < 0.01). Furthermore, levels of alkaline phosphatase showed significant correlations to mineral appositional rate, tetracycline-labelled surface and bone formation rate, volume referent (p < 0.05). Values of parathyroid hormone were significantly correlated to resorption surface (p < 0.02), active resorption surface, mineral appositional rate and mineralization lag time (p < 0.05). In conclusion, BBC was of no use in patients treated with CAPD as a noninvasive test for evaluation of bone histomorphometry. However, osteocalcin correlated best with resorption and bone dynamics indices. Levels of alkaline phosphatase and parathyroid hormone were of a more limited value.

AB - In the evaluation of renal osteodystrophy bone biopsy is often performed. However, a reliable noninvasive test could be very useful, and recently the estimation of osseous tracer uptake as an index of bone formation has been introduced-the bone bisphosphonate clearance (BBC). The aim of the present investigation therefore was to compare BBC with parameters of bone histology, serum levels of osteocalcin, alkaline phosphatase, and parathyroid hormone in patients (n = 8) undergoing continuous ambulatory peritoneal dialysis (CAPD). No significant correlations were found between BBC values and the bone histomorphometrical variables measured. A positive correlation was seen between serum osteocalcin and resorption and active resorption surface (p < 0.05), as well as tetracycline-labelled surface, bone formation rate, surfaces, volume and tissue referents, respectively (p < 0.01). Furthermore, levels of alkaline phosphatase showed significant correlations to mineral appositional rate, tetracycline-labelled surface and bone formation rate, volume referent (p < 0.05). Values of parathyroid hormone were significantly correlated to resorption surface (p < 0.02), active resorption surface, mineral appositional rate and mineralization lag time (p < 0.05). In conclusion, BBC was of no use in patients treated with CAPD as a noninvasive test for evaluation of bone histomorphometry. However, osteocalcin correlated best with resorption and bone dynamics indices. Levels of alkaline phosphatase and parathyroid hormone were of a more limited value.

M3 - Journal article

C2 - 1292341

SN - 0250-8095

VL - 12

SP - 419

EP - 424

JO - American Journal of Nephrology

JF - American Journal of Nephrology

IS - 6

ER -