@article{02cf5b00acd811ddb538000ea68e967b,
title = "Blockade of Ca2+-activated K+ channels in T cells: an option for the treatment of multiple sclerosis?",
abstract = "Voltage- and Ca(2+)-dependent K(+) channels in the membrane of both T and B lymphocytes are important for the cellular immune response. In the current issue of the European Journal of Immunology, Reich et al. demonstrate that selective blockade of the intermediate-conductance Ca(2+)-activated K(+) channel (the IK channel encoded by the KCNN4 gene) prevents cytokine production in the spinal chord and ameliorates the development of EAE caused by injection of myelin oligodendrocyte glycoprotein (MOG)(35-55) in mice. These data renew the focus on the IK channel as a potential target for the development of new immune-suppressant drugs for the treatment of autoimmune diseases.",
author = "Madsen, {Lars Siim} and Palle Christophersen and S{\o}ren-Peter Olesen",
note = "Keywords: Animals; Mice; Multiple Sclerosis; Potassium Channels, Calcium-Activated; T-Lymphocytes",
year = "2005",
doi = "10.1002/eji.200526078",
language = "English",
volume = "35",
pages = "1023--6",
journal = "European Journal of Immunology",
issn = "0014-2980",
publisher = "Wiley - V C H Verlag GmbH & Co. KGaA",
number = "4",
}