Blood-brain glucose transport in the conscious rat: comparison of the intravenous and intracarotid injection methods

Albert Gjedde; Mette Rasmussen

Blood-brain glucose transport in the conscious rat: comparison of the intravenous and intracarotid injection methods

Albert Gjedde, Mette Rasmussen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

26 Citationer (Scopus)

Abstract

Udgivelsesdato: 1980-Dec

Originalsprog	Engelsk
Tidsskrift	Journal of Neurochemistry
Vol/bind	35
Udgave nummer	6
Sider (fra-til)	1375-81
Antal sider	6
ISSN	1471-4159
Status	Udgivet - 1980
Udgivet eksternt	Ja

Citationsformater

@article{ff709660b31411debc73000ea68e967b,

title = "Blood-brain glucose transport in the conscious rat: comparison of the intravenous and intracarotid injection methods",

abstract = "The unidirectioal transfer of D-glucose from blood to parietal cortex tissue of the brain of awake rats was measured by single intravenous injection of tracer glucose, as well as by single intracarotid injection according to the method of Oldendorf. The maximal unidirectional blood-brain glucose transfer rate (Tmax) was 407 mumol (100 g)-1 min-1 when measured by intravenous injection, and 352 mumol (100 g)-1 min-1 when measured by intracarotid injection. The half-saturation constants (Km) were 7.8 mM and 16.8 mM, respectively. The comparison shows that the two methods give similar results when cerebral perfusion is assessed accurately.",

author = "Albert Gjedde and Mette Rasmussen",

year = "1980",

language = "English",

volume = "35",

pages = "1375--81",

journal = "Journal of Neurochemistry",

issn = "1471-4159",

publisher = "Wiley-Blackwell",

number = "6",

}

TY - JOUR

T1 - Blood-brain glucose transport in the conscious rat: comparison of the intravenous and intracarotid injection methods

AU - Gjedde, Albert

AU - Rasmussen, Mette

PY - 1980

Y1 - 1980

N2 - The unidirectioal transfer of D-glucose from blood to parietal cortex tissue of the brain of awake rats was measured by single intravenous injection of tracer glucose, as well as by single intracarotid injection according to the method of Oldendorf. The maximal unidirectional blood-brain glucose transfer rate (Tmax) was 407 mumol (100 g)-1 min-1 when measured by intravenous injection, and 352 mumol (100 g)-1 min-1 when measured by intracarotid injection. The half-saturation constants (Km) were 7.8 mM and 16.8 mM, respectively. The comparison shows that the two methods give similar results when cerebral perfusion is assessed accurately.

AB - The unidirectioal transfer of D-glucose from blood to parietal cortex tissue of the brain of awake rats was measured by single intravenous injection of tracer glucose, as well as by single intracarotid injection according to the method of Oldendorf. The maximal unidirectional blood-brain glucose transfer rate (Tmax) was 407 mumol (100 g)-1 min-1 when measured by intravenous injection, and 352 mumol (100 g)-1 min-1 when measured by intracarotid injection. The half-saturation constants (Km) were 7.8 mM and 16.8 mM, respectively. The comparison shows that the two methods give similar results when cerebral perfusion is assessed accurately.

M3 - Journal article

C2 - 7441255

SN - 1471-4159

VL - 35

SP - 1375

EP - 1381

JO - Journal of Neurochemistry

JF - Journal of Neurochemistry

IS - 6

ER -