BMI changes during childhood and adolescence as predictors of amount of adult subcutaneous and visceral adipose tissue in men: the GOOD Study

Jenny M Kindblom; Mattias Lorentzon; Asa Hellqvist; Lars Lönn; John Brandberg; Staffan Nilsson; Ensio Norjavaara; Claes Ohlsson

doi:10.2337/db08-0606

BMI changes during childhood and adolescence as predictors of amount of adult subcutaneous and visceral adipose tissue in men: the GOOD Study

Jenny M Kindblom, Mattias Lorentzon, Asa Hellqvist, Lars Lönn, John Brandberg, Staffan Nilsson, Ensio Norjavaara, Claes Ohlsson

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

53 Citationer (Scopus)

Abstract

Udgivelsesdato: 2009-Apr

Originalsprog	Engelsk
Tidsskrift	Diabetes
Vol/bind	58
Udgave nummer	4
Sider (fra-til)	867-74
Antal sider	7
ISSN	0012-1797
DOI	https://doi.org/10.2337/db08-0606
Status	Udgivet - 2009

Bibliografisk note

Keywords: Absorptiometry, Photon; Adipose Tissue; Adolescent; Body Composition; Body Mass Index; Child; Growth; Humans; Male; Obesity; Osteoporosis; Predictive Value of Tests; Skin; Viscera; Young Adult

Adgang til dokumentet

10.2337/db08-0606

Citationsformater

@article{988a1a5056ae11df928f000ea68e967b,

title = "BMI changes during childhood and adolescence as predictors of amount of adult subcutaneous and visceral adipose tissue in men: the GOOD Study",

abstract = "OBJECTIVE: The amount of visceral adipose tissue is a risk factor for the metabolic syndrome. It is unclear how BMI changes during childhood and adolescence predict adult fat distribution. We hypothesized that there are critical periods during development for the prediction of adult subcutaneous and visceral fat mass by BMI changes during childhood and adolescence. RESEARCH DESIGN AND METHODS: Detailed growth charts were retrieved for the men participating in the population-based Gothenburg Osteoporosis and Obesity Determinants (GOOD) Study (n = 612). Body composition was analyzed using dual-energy X-ray absorptiometry and adipose tissue areas using abdominal computed tomography at 18 to 20 years of age. RESULTS: The main finding in the present study was that subjects with increases in BMI Z score of more than 1 SD during adolescence had, independent of prepubertal BMI, both larger subcutaneous (+138%; P < 0.001) and visceral adipose tissue areas (+91%; P < 0.001) than subjects with unchanged BMI Z-score. In contrast, subjects with increases in BMI Z score of more than 1 SD during late childhood had a larger amount of adult subcutaneous adipose tissue (+83%; P < 0.001) than subjects with unchanged BMI Z score but an unaffected amount of visceral adipose tissue. BMI changes during adolescence predict both visceral and subcutaneous adipose tissue of the abdomen, whereas BMI changes during late childhood predict only the subcutaneous adipose tissue. CONCLUSIONS: The amount of visceral adipose tissue in young adult men was associated with BMI changes specifically during adolescence, whereas the amount of subcutaneous adipose tissue was associated with BMI changes during both late childhood and adolescence.",

author = "Kindblom, {Jenny M} and Mattias Lorentzon and Asa Hellqvist and Lars L{\"o}nn and John Brandberg and Staffan Nilsson and Ensio Norjavaara and Claes Ohlsson",

note = "Keywords: Absorptiometry, Photon; Adipose Tissue; Adolescent; Body Composition; Body Mass Index; Child; Growth; Humans; Male; Obesity; Osteoporosis; Predictive Value of Tests; Skin; Viscera; Young Adult",

year = "2009",

doi = "10.2337/db08-0606",

language = "English",

volume = "58",

pages = "867--74",

journal = "Diabetes",

issn = "0012-1797",

publisher = "American Diabetes Association",

number = "4",

}

TY - JOUR

T1 - BMI changes during childhood and adolescence as predictors of amount of adult subcutaneous and visceral adipose tissue in men: the GOOD Study

AU - Kindblom, Jenny M

AU - Lorentzon, Mattias

AU - Hellqvist, Asa

AU - Lönn, Lars

AU - Brandberg, John

AU - Nilsson, Staffan

AU - Norjavaara, Ensio

AU - Ohlsson, Claes

N1 - Keywords: Absorptiometry, Photon; Adipose Tissue; Adolescent; Body Composition; Body Mass Index; Child; Growth; Humans; Male; Obesity; Osteoporosis; Predictive Value of Tests; Skin; Viscera; Young Adult

PY - 2009

Y1 - 2009

N2 - OBJECTIVE: The amount of visceral adipose tissue is a risk factor for the metabolic syndrome. It is unclear how BMI changes during childhood and adolescence predict adult fat distribution. We hypothesized that there are critical periods during development for the prediction of adult subcutaneous and visceral fat mass by BMI changes during childhood and adolescence. RESEARCH DESIGN AND METHODS: Detailed growth charts were retrieved for the men participating in the population-based Gothenburg Osteoporosis and Obesity Determinants (GOOD) Study (n = 612). Body composition was analyzed using dual-energy X-ray absorptiometry and adipose tissue areas using abdominal computed tomography at 18 to 20 years of age. RESULTS: The main finding in the present study was that subjects with increases in BMI Z score of more than 1 SD during adolescence had, independent of prepubertal BMI, both larger subcutaneous (+138%; P < 0.001) and visceral adipose tissue areas (+91%; P < 0.001) than subjects with unchanged BMI Z-score. In contrast, subjects with increases in BMI Z score of more than 1 SD during late childhood had a larger amount of adult subcutaneous adipose tissue (+83%; P < 0.001) than subjects with unchanged BMI Z score but an unaffected amount of visceral adipose tissue. BMI changes during adolescence predict both visceral and subcutaneous adipose tissue of the abdomen, whereas BMI changes during late childhood predict only the subcutaneous adipose tissue. CONCLUSIONS: The amount of visceral adipose tissue in young adult men was associated with BMI changes specifically during adolescence, whereas the amount of subcutaneous adipose tissue was associated with BMI changes during both late childhood and adolescence.

AB - OBJECTIVE: The amount of visceral adipose tissue is a risk factor for the metabolic syndrome. It is unclear how BMI changes during childhood and adolescence predict adult fat distribution. We hypothesized that there are critical periods during development for the prediction of adult subcutaneous and visceral fat mass by BMI changes during childhood and adolescence. RESEARCH DESIGN AND METHODS: Detailed growth charts were retrieved for the men participating in the population-based Gothenburg Osteoporosis and Obesity Determinants (GOOD) Study (n = 612). Body composition was analyzed using dual-energy X-ray absorptiometry and adipose tissue areas using abdominal computed tomography at 18 to 20 years of age. RESULTS: The main finding in the present study was that subjects with increases in BMI Z score of more than 1 SD during adolescence had, independent of prepubertal BMI, both larger subcutaneous (+138%; P < 0.001) and visceral adipose tissue areas (+91%; P < 0.001) than subjects with unchanged BMI Z-score. In contrast, subjects with increases in BMI Z score of more than 1 SD during late childhood had a larger amount of adult subcutaneous adipose tissue (+83%; P < 0.001) than subjects with unchanged BMI Z score but an unaffected amount of visceral adipose tissue. BMI changes during adolescence predict both visceral and subcutaneous adipose tissue of the abdomen, whereas BMI changes during late childhood predict only the subcutaneous adipose tissue. CONCLUSIONS: The amount of visceral adipose tissue in young adult men was associated with BMI changes specifically during adolescence, whereas the amount of subcutaneous adipose tissue was associated with BMI changes during both late childhood and adolescence.

U2 - 10.2337/db08-0606

DO - 10.2337/db08-0606

M3 - Journal article

C2 - 19168597

SN - 0012-1797

VL - 58

SP - 867

EP - 874

JO - Diabetes

JF - Diabetes

IS - 4

ER -