Breast Cancer Histopathology in the Age of Molecular Oncology

Zuzana Kos, Torsten O. Nielsen, Anne Vibeke Laenkholm

Publikation: Bidrag til tidsskriftReviewForskningpeer review

1 Citationer (Scopus)

Abstract

For more than a century, microscopic histology has been the cornerstone for cancer diagnosis, and breast carcinoma is no exception. In recent years, clinical biomarkers, gene expression profiles, and other molecular tests have shown increasing utility for identifying the key biological features that guide prognosis and treatment of breast cancer. Indeed, the most common histologic pattern—invasive ductal carcinoma of no special type—provides relatively little guidance to management beyond triggering grading, biomarker testing, and clinical staging. However, many less common histologic patterns can be recognized by trained pathologists, which in many cases can be linked to characteristic biomarker and gene expression patterns, underlying mutations, prognosis, and therapy. Herein we describe more than a dozen such histomorphologic subtypes (including lobular, metaplastic, salivary analog, and several good prognosis special types of breast cancer) in the context of their molecular and clinical features.
OriginalsprogEngelsk
TidsskriftCold Spring Harbor Perspectives in Medicine
Vol/bind14
Udgave nummer6
ISSN2157-1422
DOI
StatusUdgivet - 2024

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