@article{530f1bb0abf111ddb5e9000ea68e967b,
title = "Bronchial histamine challenge in the diagnosis of asthma. The predictive value of changes in airway resistance determined by the interrupter method.",
abstract = "The predictive value of a bronchial challenge with histamine was determined in a prospective survey on a population with a high prevalence of asthma (0.62). Without knowledge of the bronchial responsiveness 133 patients were classified as asthmatics (83) or non-asthmatics (50) according to variation in peak expiratory flow rate and medical history. Response to challenge was determined by the interrupter method, and the concentration of histamine inducing a 40% increase in resistance to breathing (PC40-Rt) was calculated from the log dose response curve. When defining a positive test as a test giving PC40-Rt-values below 2.00 mg/ml, the predictive value of a positive test was 0.75 and the predictive value of a negative test was 0.72. By decreasing the limit for a positive test to 0.25 mg/ml the corresponding predictive value was increased to 0.91. When further increasing the limit to 4.00 mg/ml the predictive value of a negative test in the diagnosis of asthma was increased to 0.81. The interrupter technique is suitable for diagnostic purposes in the detection and exclusion of bronchial asthma.",
author = "F Madsen and Holstein-Rathlou, {N H} and L Fr{\o}lund and B Weeke and Svendsen, {U G}",
note = "Keywords: Adolescent; Adult; Aged; Airway Resistance; Asthma; Bronchial Provocation Tests; Cross-Sectional Studies; Female; Forced Expiratory Flow Rates; Histamine; Humans; Male; Middle Aged; Pregnancy; Respiration",
year = "1986",
language = "English",
volume = "41",
pages = "187--95",
journal = "Allergy: European Journal of Allergy and Clinical Immunology",
issn = "0105-4538",
publisher = "Wiley Online",
number = "3",
}