Bulk characterization of pharmaceutical powders by low-pressure compression II: effect of method settings and particle size

A. Hagsten Sørensen, Jørn Sonnergaard, L. Hovgaard

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

7 Citationer (Scopus)

Abstract

The aim of the present study was to investigate the effect of punch and die diameter, sample size, compression speed, and particle size on two low-pressure compression-derived parameters; the compressed density and the Walker w parameter. The excellent repeatability of the low-pressure compression method allowed small effects of variations in punch and die diameter and sample size to be demonstrated on a high significance level. Changing the compression speed, however, did not cause a significant effect in the compressed density, whereas a decrease in w was seen. The effect of particle size was studied by compressing and tapping different grades of calcium carbonate, lactose, and microcrystalline cellulose. The low-pressure compression-derived parameters were compared to tapped densities and to Compressibility Indexes obtained by tapping volumetry. Even though the relationship between particle size and the low-pressure compression-derived parameters appeared to be more complicated, a similar trend was observed. It was concluded that the low-pressure compression method provides a useful alternative to the more sample-consuming methods providing flow-related information.
OriginalsprogEngelsk
TidsskriftPharmaceutical Development and Technology
Vol/bind11
Udgave nummer2
Sider (fra-til)235-241
Antal sider7
ISSN1083-7450
DOI
StatusUdgivet - 1 maj 2006

Citationsformater