TY - JOUR
T1 - C-reactive protein, genetically elevated levels and risk of ischemic heart and cerebrovascular disease
AU - Zacho, Jeppe
AU - Tybjaerg-Hansen, Anne
AU - Nordestgaard, Børge Grønne
N1 - Keywords: C-Reactive Protein; Cerebrovascular Disorders; Humans; Myocardial Ischemia; Risk Factors
PY - 2009
Y1 - 2009
N2 - We tested whether genetically elevated levels of C-reactive protein (CRP) cause increased risk of ischemic heart disease and ischemic cerebrovascular disease. Levels of CRP >3mg/L, compared with levels <1mg/L, associated with a 1.6- and 1.3-fold increased risk of ischemic heart disease and ischemic cerebrovascular disease. Genotype combinations of the 4 CRP polymorphisms associated with up to a 64% increase in CRP levels, resulting in a theoretically predicted increased risk of up to 32% for ischemic heart disease and up to 25% for ischemic cerebrovascular disease. However, these genotype combinations did not associate with increased risk of ischemic heart and cerebrovascular disease.
AB - We tested whether genetically elevated levels of C-reactive protein (CRP) cause increased risk of ischemic heart disease and ischemic cerebrovascular disease. Levels of CRP >3mg/L, compared with levels <1mg/L, associated with a 1.6- and 1.3-fold increased risk of ischemic heart disease and ischemic cerebrovascular disease. Genotype combinations of the 4 CRP polymorphisms associated with up to a 64% increase in CRP levels, resulting in a theoretically predicted increased risk of up to 32% for ischemic heart disease and up to 25% for ischemic cerebrovascular disease. However, these genotype combinations did not associate with increased risk of ischemic heart and cerebrovascular disease.
U2 - 10.1080/00365510903056015
DO - 10.1080/00365510903056015
M3 - Journal article
C2 - 19533498
VL - 69
SP - 442
EP - 446
JO - Scandinavian Journal of Clinical & Laboratory Investigation
JF - Scandinavian Journal of Clinical & Laboratory Investigation
SN - 0036-5513
IS - 4
ER -