C-reaktivt protein og risiko for iskaemisk hjerte- og cerebrovaskulaer sygdom--sekundaerpublikation

Jeppe Zacho, Anne Tybjaerg-Hansen, Jan Skov Jensen, Peer Grande, Henrik Sillesen, Børge G Nordestgaard

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstract

Elevated levels of C reactive protein (CRP) are associated with increased risk of ischaemic vascular disease. We tested whether this is a causal association. CRP > 3 vs < 1 mg/l were associated with an increased risk of ischaemic heart- and cerebrovascular disease of 1.6 and 1.3, respectively. Four CRP polymorphisms were associated with a 64% increase in CRP levels, resulting in a theoretically predicted increased risk of 32% and 25% for ischemic heart- and ischemic cerebrovascular disease, respectively. However, these genotype combinations were not associated with an increased risk of ischaemic vascular disease.
Udgivelsesdato: 2009-May
Bidragets oversatte titelC-reactive protein and risk of ischaemic vascular and cerebrovascular disease--secondary publication
OriginalsprogDansk
TidsskriftUgeskrift for læger
Vol/bind171
Udgave nummer21
Sider (fra-til)1751-5
Antal sider5
ISSN0041-5782
StatusUdgivet - 2009

Bibliografisk note

Keywords: Atherosclerosis; Biological Markers; C-Reactive Protein; Cerebrovascular Disorders; Cohort Studies; Genetic Predisposition to Disease; Genotype; Humans; Myocardial Ischemia; Polymorphism, Genetic; Risk Factors

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