C-reaktivt protein og risiko for iskaemisk hjerte- og cerebrovaskulaer sygdom--sekundaerpublikation

Jeppe Zacho; Anne Tybjaerg-Hansen; Jan Skov Jensen; Peer Grande; Henrik Sillesen; Børge G Nordestgaard

C-reaktivt protein og risiko for iskaemisk hjerte- og cerebrovaskulaer sygdom--sekundaerpublikation

Jeppe Zacho, Anne Tybjaerg-Hansen, Jan Skov Jensen, Peer Grande, Henrik Sillesen, Børge G Nordestgaard

Ph.d.-studienævnet for Medicin

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Elevated levels of C reactive protein (CRP) are associated with increased risk of ischaemic vascular disease. We tested whether this is a causal association. CRP > 3 vs < 1 mg/l were associated with an increased risk of ischaemic heart- and cerebrovascular disease of 1.6 and 1.3, respectively. Four CRP polymorphisms were associated with a 64% increase in CRP levels, resulting in a theoretically predicted increased risk of 32% and 25% for ischemic heart- and ischemic cerebrovascular disease, respectively. However, these genotype combinations were not associated with an increased risk of ischaemic vascular disease.
Udgivelsesdato: 2009-May

Bidragets oversatte titel	C-reactive protein and risk of ischaemic vascular and cerebrovascular disease--secondary publication
Originalsprog	Dansk
Tidsskrift	Ugeskrift for læger
Vol/bind	171
Udgave nummer	21
Sider (fra-til)	1751-5
Antal sider	5
ISSN	0041-5782
Status	Udgivet - 2009

Bibliografisk note

Keywords: Atherosclerosis; Biological Markers; C-Reactive Protein; Cerebrovascular Disorders; Cohort Studies; Genetic Predisposition to Disease; Genotype; Humans; Myocardial Ischemia; Polymorphism, Genetic; Risk Factors

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Citationsformater

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abstract = "Elevated levels of C reactive protein (CRP) are associated with increased risk of ischaemic vascular disease. We tested whether this is a causal association. CRP > 3 vs < 1 mg/l were associated with an increased risk of ischaemic heart- and cerebrovascular disease of 1.6 and 1.3, respectively. Four CRP polymorphisms were associated with a 64% increase in CRP levels, resulting in a theoretically predicted increased risk of 32% and 25% for ischemic heart- and ischemic cerebrovascular disease, respectively. However, these genotype combinations were not associated with an increased risk of ischaemic vascular disease. Udgivelsesdato: 2009-May",

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note = "Keywords: Atherosclerosis; Biological Markers; C-Reactive Protein; Cerebrovascular Disorders; Cohort Studies; Genetic Predisposition to Disease; Genotype; Humans; Myocardial Ischemia; Polymorphism, Genetic; Risk Factors",

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T1 - C-reaktivt protein og risiko for iskaemisk hjerte- og cerebrovaskulaer sygdom--sekundaerpublikation

AU - Zacho, Jeppe

AU - Tybjaerg-Hansen, Anne

AU - Jensen, Jan Skov

AU - Grande, Peer

AU - Sillesen, Henrik

AU - Nordestgaard, Børge G

N1 - Keywords: Atherosclerosis; Biological Markers; C-Reactive Protein; Cerebrovascular Disorders; Cohort Studies; Genetic Predisposition to Disease; Genotype; Humans; Myocardial Ischemia; Polymorphism, Genetic; Risk Factors

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N2 - Elevated levels of C reactive protein (CRP) are associated with increased risk of ischaemic vascular disease. We tested whether this is a causal association. CRP > 3 vs < 1 mg/l were associated with an increased risk of ischaemic heart- and cerebrovascular disease of 1.6 and 1.3, respectively. Four CRP polymorphisms were associated with a 64% increase in CRP levels, resulting in a theoretically predicted increased risk of 32% and 25% for ischemic heart- and ischemic cerebrovascular disease, respectively. However, these genotype combinations were not associated with an increased risk of ischaemic vascular disease. Udgivelsesdato: 2009-May

AB - Elevated levels of C reactive protein (CRP) are associated with increased risk of ischaemic vascular disease. We tested whether this is a causal association. CRP > 3 vs < 1 mg/l were associated with an increased risk of ischaemic heart- and cerebrovascular disease of 1.6 and 1.3, respectively. Four CRP polymorphisms were associated with a 64% increase in CRP levels, resulting in a theoretically predicted increased risk of 32% and 25% for ischemic heart- and ischemic cerebrovascular disease, respectively. However, these genotype combinations were not associated with an increased risk of ischaemic vascular disease. Udgivelsesdato: 2009-May

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C2 - 19492468

SN - 0041-5782

VL - 171

SP - 1751

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JO - Ugeskrift for læger

JF - Ugeskrift for læger

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