Abstract
A large variety of C-terminally modified peptides was obtained by nucleophilic cleavage of the ester bond in solid phase linked peptide esters of 4-hydroxymethyl benzamide (HMBA). The developed methods provided peptides, C-terminally functionalized as esters, amides and thioesters, with high purity directly from the resin in a single reaction step. A comprehensive screening of the reaction conditions and scope for nucleophilic cleavage of peptides from the HMBA linker was performed.
Originalsprog | Engelsk |
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Tidsskrift | Organic & Biomolecular Chemistry |
Vol/bind | 14 |
Udgave nummer | 12 |
Sider (fra-til) | 3238-3245 |
Antal sider | 8 |
ISSN | 1477-0520 |
DOI | |
Status | Udgivet - 2016 |