C24 Sphingolipids Govern the Transbilayer Asymmetry of Cholesterol and Lateral Organization of Model and Live-Cell Plasma Membranes

K. C. Courtney, W. Pezeshkian, R. Raghupathy, C. Zhang, A. Darbyson, J. H. Ipsen, D. A. Ford, H. Khandelia, J. F. Presley, X. Zha*

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

58 Citationer (Scopus)
1 Downloads (Pure)

Abstract

Sphingolipids, mostly C24, reside in the exoplasmic leaflet of the plasma membrane in mammalian cells. Courtney et al. find that C24 sphingomyelin (SM), unlike C16 or C18 SM, dictates cholesterol partitioning between leaflets and, consequently, controls the formation of microdomains in membranes.

OriginalsprogEngelsk
TidsskriftCell Reports
Vol/bind24
Udgave nummer4
Sider (fra-til)1037-1049
Antal sider13
ISSN2211-1247
DOI
StatusUdgivet - 2018
Udgivet eksterntJa

Citationsformater