C3G self-regulatory mechanism revealed: implications for hematopoietic malignancies

Arturo Carabias; Carmen Guerrero; José M. de Pereda

doi:10.1080/23723556.2020.1837581

C3G self-regulatory mechanism revealed: implications for hematopoietic malignancies

Arturo Carabias, Carmen Guerrero, José M. de Pereda^*

^*Corresponding author af dette arbejde

Montoya Group

Publikation: Bidrag til tidsskrift › Kommentar/debat › Forskning › peer review

1 Citationer (Scopus)

9 Downloads (Pure)

Abstract

Abnormally increased signaling by the GTPase RAP1 favors progression of diverse tumors. We have characterized the auto-regulation and activation of C3G (RAPGEF1), an activator of RAP1. This led us to discover mutations in non-Hodgkin’s lymphomas that activate C3G-RAP1 constitutively, suggesting that deregulation of C3G may favor the dissemination of tumor cells.

Originalsprog	Engelsk
Artikelnummer	1837581
Tidsskrift	Molecular and Cellular Oncology
Vol/bind	8
Udgave nummer	1
Antal sider	4
ISSN	2372-3556
DOI	https://doi.org/10.1080/23723556.2020.1837581
Status	Udgivet - 2021

Adgang til dokumentet

10.1080/23723556.2020.1837581

FulltextForlagets udgivne version, 1,57 MBLicens: CC BY-NC-ND

Citationsformater

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