Cad1 turns ATP into phage poison

Jinzhong Lin; Yuvaraj Bhoobalan-Chitty; Xu Peng

doi:10.1016/j.chom.2024.12.013

Cad1 turns ATP into phage poison

Jinzhong Lin, Yuvaraj Bhoobalan-Chitty, Xu Peng^*

^*Corresponding author af dette arbejde

Functional genomics

Publikation: Bidrag til tidsskrift › Kommentar/debat › Forskning › peer review

Abstract

Type III CRISPR-Cas executes a multifaceted anti-phage response, activating effectors such as a nuclease or membrane depolarizer. In a recent Cell paper, Baca and Majumder et al.1 report an accessory effector, Cad1, which deaminates ATP into ITP, causing ITP accumulation and host growth arrest, thereby inhibiting phage propagation.

Originalsprog	Engelsk
Tidsskrift	Cell Host and Microbe
Vol/bind	33
Udgave nummer	1
Sider (fra-til)	8-10
Antal sider	3
ISSN	1931-3128
DOI	https://doi.org/10.1016/j.chom.2024.12.013
Status	Udgivet - 2025

Bibliografisk note

Publisher Copyright:
© 2024 Elsevier Inc.

Adgang til dokumentet

10.1016/j.chom.2024.12.013

Citationsformater

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AB - Type III CRISPR-Cas executes a multifaceted anti-phage response, activating effectors such as a nuclease or membrane depolarizer. In a recent Cell paper, Baca and Majumder et al.1 report an accessory effector, Cad1, which deaminates ATP into ITP, causing ITP accumulation and host growth arrest, thereby inhibiting phage propagation.

U2 - 10.1016/j.chom.2024.12.013

DO - 10.1016/j.chom.2024.12.013

M3 - Comment/debate

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AN - SCOPUS:85213840602

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